Vitamin D Decreases Risk of Breast Cancer in Premenopausal Women of Normal Weight in Subtropical Taiwan

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概要

• 論文の詳細を見る

• Background: Evidence for an association between vitamin D status and breast cancer is now more convincing, but is uncertain in subtropical areas like Taiwan. This hospital-based case-control study examined the relationship of breast cancer with vitamin D intake and sunlight exposure.Methods: A total of 200 incident breast cancer cases in a Taipei hospital were matched with 200 controls by date of interview and menopausal status. Information on risk factors for breast cancer was collected in face-to-face interviews and assessed with reference to vitamin D intake (foods and nutrients) and sunlight exposure. Vitamin D intake was divided into quartiles, and threshold effect was evaluated by comparing Q2–Q4 with Q1.Results: After controlling for age, education, parity, hormone replacement therapy, body mass index (BMI), energy intake, menopausal status, and daily sunlight exposure, the risk of breast cancer in participants with a dietary vitamin D intake greater than 5 µg per day was significantly lower (odds ratio [OR], 0.48; 95% confidence interval [CI], 0.24–0.97) than that of participants with an intake less than 2 µg per day. In analysis stratified by menopausal status and BMI, both dietary vitamin D and total vitamin D intakes were associated with a protective effect among premenopausal women. There was a significant linear trend for breast cancer risk and dietary vitamin D intake in premenopausal women (P = 0.02). In participants with a BMI lower than 24 kg/m2 (ie, normal weight), dietary vitamin D intake was inversely related to breast cancer risk (P for trend = 0.002), and a threshold effect was apparent (Q2–Q4 vs Q1: OR, 0.46; 95% CI, 0.23–0.90).Conclusions: Vitamin D had a protective effect against breast cancer in premenopausal women of normal weight in subtropical Taiwan, especially an intake greater than 5 µg per day.

• 日本疫学会の論文
• 2011-03-01

著者

• YU JYH-CHERNG

  Department of Surgery, National Defense Medical Center, Tri-Service General Hospital

• Sun Chien-an

  Department Of Public Health College Of Medicine Fu-jen Catholic University

• Chou Yu-ching

  School Of Public Health National Defense Medical Center

• LEE Meei-Shyuan

  School of Public Health, National Defense Medical Center

• HUANG Yi-Chen

  School of Public Health, National Defense Medical Center

• WAHLQVIST Mark

  School of Public Health, National Defense Medical Center

• WU Tsai-Yi

  School of Public Health, National Defense Medical Center

• WU Mei-Hsuan

  Graduate Institute of Medical Sciences, National Defense Medical Center

• Wahlqvist Mark

  School Of Public Health National Defense Medical Center

• Lee Meei-shyuan

  School Of Public Health National Defense Medical Center

• Wu Mei-hsuan

  Graduate Institute Of Medical Sciences National Defense Medical Center

• Wu Tsai-yi

  School Of Public Health National Defense Medical Center

• Huang Yi-chen

  School Of Public Health National Defense Medical Center

• Yu Jyh-cherng

  Department Of Surgery Tri-service General Hospital

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• Vitamin D Decreases Risk of Breast Cancer in Premenopausal Women of Normal Weight in Subtropical Taiwan

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