Pleiotropic Role of AIM in Lymphocyte Apoptosis and Inflammation
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概要
- 論文の詳細を見る
Apoptosis of cells must be managed both positively and negatively in response to various environmental stresses via differential signal transduction cascades. Recently, an apoptosis inhibitor expressed by macrophages (AIM) was presented as a novel murine soluble protein. AIM is a member of the macrophage scavenger receptor, cysteine-rich domain superfamily (SRCR-SF), which shares a highly homologous-conserved, cysteine-rich domain. AIM inhibits the apoptosis of CD4+CD8+ (CD4/CD8) double-positive (DP) thymocytes, and supports the viability of these cells in T cell development in the thymus. In inflammatory sites outside the thymus, AIM appears to enhance macrophage phagocytosis, inhibit B cell proliferation in combination with transforming growth factor-β and inhibit apoptosis of natural killer T (NKT) and natural killer (NK) cells. AIM thus has diverse functions that depend on the type of target cell and its combination with other cytokines.
- 日本リンパ網内系学会の論文
- 2004-04-01
著者
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Watanabe Hisami
Division Of Cellular And Molecular Immunology Center Of Molecular Bioscience Ryukyu University
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Naito Makoto
Department Of Aeronautical Engineering Faculty Of Engineering Kyoto University
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Naito Makoto
Department Of Cellular Function Division Of Cellular And Molecular Pathology Niigata University Grad
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Miyazaki Toru
Center For Immunology The University Of Texas Southwestern Medical Center
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Kuwata Kazuhisa
Department Of Cellular Function Division Of Cellular And Molecular Pathology Niigata University Grad
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Watanabe Hisami
Division Of Cellular And Molecular Immunology Center Of Molecular Biosciences University Of The Ryuk
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