Non-Toxic Cadmium Concentrations Induce Vascular Inflammation and Promote Atherosclerosis

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概要

• 論文の詳細を見る

• Background: Cadmium is a potential new risk factor for early atherosclerosis and cardiovascular diseases in humans, yet pathogenetic mechanisms are still a matter of debate. Methods and Results: In-depth histological analysis of 18 sections taken from 6 cadmium-fed ApoE-/- mice and 12 sections from 5 litter-mates not exposed to cadmium by light and scanning electron microscopy was performed. Cadmium-fed mice showed a marked increase in lesion load (plaque area) and severity as classified according to the American Heart Association vascular lesion grading. All inflammatory markers studied (CD68, CD3, CD25, vascular cell adhesion molecule 1 (VCAM-1), and heat shock protein 60 (Hsp60)) yielded a higher expression in cadmium-fed mice. Statistical difference was achieved for VCAM-1 and Hsp60 (P=0.03 and P=0.02). The shoulder region of atherosclerotic plaques in cadmium-fed mice showed a prominent retraction of endothelial cells on electron microscopy. Conclusions: Our data indicate that cadmium exposure amplifies the development of vessel pathology in atherosclerosis susceptible ApoE-/- mice and suggests upregulation of VCAM-1 and Hsp60 and endothelial leakage as potential pathomechanisms. (Circ J 2011; 75: 2491-2495)

• 2011-09-25

著者

• Shen Ying

  Department Of Neonatology Children's Hospital Zhejiang University School Of Medicine

• Pfaller Kristian

  Division Of Histology And Embryology Medical University Of Innsbruck

• Laufer Gunther

  Department Of Surgery Medical University Of Vienna

• Bernhard David

  Department Of Surgery Medical University Of Vienna

• Kiechl Stefan

  Department Of Neurology Innsbruck Medical University

• KNOFLACH Michael

  Department of Neurology, Innsbruck Medical University

• MESSNER Barbera

  Department of Surgery, Medical University of Vienna

• FROTSCHNIG Sandra

  Cardiac Surgery Research Laboratory, Department of Cardiac Surgery, Innsbruck Medical University

• LIU Guanghui

  Department of Surgery, Baylor College of Medicine

• WANG Xingli

  Department of Surgery, Baylor College of Medicine

• MATOSEVIC Benjamin

  Department of Neurology, Innsbruck Medical University

• WILLEIT Johann

  Department of Neurology, Innsbruck Medical University

• Shen Ying

  Department Of Surgery Baylor College Of Medicine

• Messner Barbera

  Department Of Surgery Medical University Of Vienna

• Wang Xingli

  Department Of Surgery Baylor College Of Medicine

• Liu Guanghui

  Department Of Surgery Baylor College Of Medicine

• Willeit Johann

  Department Of Neurology Innsbruck Medical University

• Knoflach Michael

  Department Of Neurology Innsbruck Medical University

• Pfaller Kristian

  Division Of Histology And Embryology Innsbruck Medical University

• Frotschnig Sandra

  Cardiac Surgery Research Laboratory Department Of Cardiac Surgery Innsbruck Medical University

• Matosevic Benjamin

  Department Of Neurology Innsbruck Medical University

関連論文

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• Erythropoietin attenuates white matter damage, proinflammatory cytokine and chemokine induction in developing rat brain after intra-uterine infection
• Non-Toxic Cadmium Concentrations Induce Vascular Inflammation and Promote Atherosclerosis

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