Molecular Characteristics of Water-Soluble Extracts from Hypsizigus marmoreus and Their in Vitro Growth Inhibition of Various Cancer Cell Lines and Immunomodulatory Function in Raw 264.7 Cells

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概要

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• Water-soluble extracts isolated from Hypsizigus marmoreus and fractionated by ion-exchange chromatography were investigated to determine their molecular characteristics and biological activities. The crude and fractionated water-soluble extracts (F1, F2 and F3) consisted mostly of carbohydrates (55.8–98.9%) with varied protein contents (1.1–23.0%). Their monosaccharide levels were significantly different, including the glucose content (67.0–100%) and galactose content (0–33.0%). The backbone of each fraction was mainly glucose molecules connected with 1,4-glycosidic linkages which contained considerable amounts of glucose and/or galactose connected through 1,6-glycosidic linkages. The average molecular weight (Mw) of the extracts varied considerably, ranging from 1,665×104 to 19×104 g/mol. Little cytotoxicity was apparent in cancer cell lines from the addition of these extracts; however, they significantly stimulated Raw 264.7 cells to release nitric oxide (NO) and prostaglandin E2 (PGE2), suggesting their potential immunomodulating activities.

• 2011-05-23

著者

• YOU SangGuan

  Department of Marine Food Science and Technology, Gangneung-Wonju National University

• Bao Honghui

  Department Of Marine Food Science And Technology Gangneung-wonju National University

• You Sangguan

  Department Of Marine Food Science And Technology Gangneung-wonju National University

関連論文

• Molecular Characteristics of Water-Soluble Extracts from Hypsizigus marmoreus and Their in Vitro Growth Inhibition of Various Cancer Cell Lines and Immunomodulatory Function in Raw 264.7 Cells
• Effect of Sulfated Modification on the Molecular Characteristics and Biological Activities of Polysaccharides from Hypsizigus marmoreus

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