Endocardial and Epicardial Deformations in Cardiac Amyloidosis and Hypertrophic Cardiomyopathy : 2-D Feature Strain Echocardiography

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概要

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• Background: The aim of the present study was to analyze epicardial (EPI) and endocardial (ENDO) strain (S) in patients with transthyretin-related cardiac amyloidosis (TTR-CA) and hypertrophic cardiomyopathy (HCM) using echocardiography (TTE) with 2-dimensional feature tracking imaging (FTI). Methods and Results: Thirty-three subjects (11 with HCM, 11 with TTR-CA, and 11 healthy subjects as controls) with a New York Heart Association functional class ≤II underwent conventional TTE and FTI. TTE was used for the evaluation of left ventricle (LV) wall thickness, mass, systolic and diastolic function. FTI was used for the evaluation of EPI and ENDO longitudinal, and circumferential, and radial S. LV wall thickness and mass were higher in both TTR-CA and HCM in comparison with controls (P<0.001), but ejection fraction (EF) was similar among patients with TTR-CA, HCM and controls (63±6%, 64±6%, 61±5%, respectively). ENDO and EPI longitudinal and circumferential S and radial S were significantly lower in HCM and TTR-CA when compared with controls (P<0.01). No differences in EPI and ENDO longitudinal S, ENDO circumferential S and radial S were found between TTR-CA and HCM groups, while EPI circumferential S was significantly lower in the TTRCA group (6±3.3%) than in the HCM group (8.1±4.3%; P<0.0001). Conclusions: Longitudinal, circumferential and radial LV deformations are impaired in patients with TTR-CA and HCM with a preserved EF. Impairment of EPI circumferential strain is greater in TTR-CA than in HCM. (Circ J 2011; 75: 1200-1208)

• 2011-04-25

著者

• Di Leo

  Department Of Chemotherapy Jules Bordet Institute

• Baldari Sergio

  Department Of Radiological Sciences Operative Unit Of Nuclear Medicine University Of Messina

• ZITO Concetta

  Clinical and Experimental Department of Medicine and Pharmacology, University of Messina

• MINUTOLI Fabio

  Department of Radiological Science, University of Messina

• Di Bella

  Clinical And Experimental Department Of Medicine And Pharmacology University Of Messina

• Zito Concetta

  Clinical And Experimental Department Of Medicine And Pharmacology University Of Messina

• Minutoli Fabio

  Department Of Radiological Sciences University Of Messina

• Carerj Scipione

  Clinical And Experimental Department Of Medicine And Pharmacology University Of Messina

• Pingitore Alessandro

  Clinical Physiology Institute Cnr Fondazione G. Monasterio Cnr Regione Toscana University Of Messina

• MAZZEO Anna

  Department of Neurosciences, Psychiatry and Anaesthesiology, University of Messina

• AQUARO Giovanni

  Clinical Physiology Institute, CNR, Fondazione G. Monasterio, CNR Regione Toscana, University of Mes

• RECUPERO Antonino

  Clinical and Experimental Department of Medicine and Pharmacology, University of Messina

• STANCANELLI Claudia

  Department of Neurosciences, Psychiatry and Anaesthesiology, University of Messina

• VITA Giuseppe

  Department of Neurosciences, Psychiatry and Anaesthesiology, University of Messina

• Mazzeo Anna

  Department Of Neurosciences Psychiatry And Anaesthesiology University Of Messina

• Vita Giuseppe

  Department Of Neurosciences Psychiatry And Anaesthesiology University Of Messina

• Aquaro Giovanni

  Clinical Physiology Institute Cnr Fondazione G. Monasterio Cnr Regione Toscana University Of Messina

• Baldari Sergio

  Department Of Radiological Sciences University Of Messina

• Stancanelli Claudia

  Department Of Neurosciences Psychiatry And Anaesthesiology University Of Messina

• Di Leo

  Department Of Neurosciences Psychiatry And Anaesthesiology University Of Messina

• Recupero Antonino

  Clinical And Experimental Department Of Medicine And Pharmacology University Of Messina

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