Long-Term Benefit of the TAXUS Liberte Stent in Small Vessels and Long Lesions : TAXUS ATLAS Program

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概要

• 論文の詳細を見る

• Background: The long-term impact of treating de novo coronary lesions in native vessels and challenging small vessel and long lesion subsets with TAXUS Liberté stents is unknown. This report examines the 3-year efficacy and safety from the TAXUS ATLAS program. Methods and Results: TAXUS ATLAS WH, Small Vessel, and Long Lesion are non-randomized studies comparing TAXUS Liberté (n=871), TAXUS Liberté 2.25mm (n=261), and TAXUS Liberté 38mm (n=150) stents, respectively, to case-matched TAXUS Express historical controls. TAXUS Liberté demonstrated comparable 3-year rates of major adverse cardiac events (19.0% vs. 20.2%, P=0.51) in de novo lesions, reduced target lesion revascularization (TLR, 10.0% vs. 22.1%, P=0.008) in small vessels, and reduced myocardial infarction (MI, 2.9% vs. 10.4%; P=0.01) and stent thrombosis (ST, 0.0% vs. 3.9%, P=0.03) in long lesions vs. TAXUS Express. After propensity score adjustment, no statistically significant effect of TAXUS Liberté on TLR (9.7% vs. 16.9%, P=0.12) in small vessels or MI (2.9% vs. 7.9%, P=0.05) in long lesions was noted, although reduced ST (0.0% vs. 2.7%, P=0.02) remained in long lesions. Multivariate analyses demonstrated that TAXUS Liberté treatment significantly reduced TLR by 66% in small vessels, and MI by 75% in long lesions, vs. TAXUS Express. Conclusions: TAXUS Liberté suggests durable 3-year effectiveness in reducing restenosis and improved clinical outcomes in small vessels and long lesions compared with TAXUS Express. (Circ J 2011; 75: 1120-1129)

• 2011-04-25

著者

• Dawkins Keith

  Boston Scientific Corporation

• Hall Jack

  The Heart Center St Vincent's Hospital

• ORMISTON John

  Mercy Angiography Unit, Mercy Hospital

• TURCO Mark

  Center for Cardiac & Vascular Research, Washington Adventist Hospital

• CANNON Louis

  Cardiac & Vascular Research Center, Northern Michigan Regional Health Systems

• YAKUBOV Steven

  Ohio Health Research Institute, Riverside Methodist Hospital

• LUCCA Michael

  Department of Education & Research, St Mary's Duluth Clinic Regional Heart Center

• STONE Gregg

  Center for Interventional Vascular Therapy, Columbia University Medical Center

• KOZINA Joseph

  Mercy Heart & Vascular Institute, Mercy General Hospital

• GILCHRIST Ian

  Heart & Vascular Institute, Milton S Hershey Medical Center

• BERTOLET Barry

  Cardiology Associates of North Mississippi, North Mississippi Medical Center

• WORTHLEY Stephen

  University of Adelaide, Royal Adelaide Hospital

• UNDERWOOD Paul

  Boston Scientific Corporation

• Turco Mark

  Center For Cardiac & Vascular Research Washington Adventist Hospital

• Stone Gregg

  Center For Interventional Vascular Therapy Columbia University Medical Center

• Cannon Louis

  Cardiac & Vascular Research Center Northern Michigan Regional Health Systems

• Kozina Joseph

  Mercy Heart & Vascular Institute Mercy General Hospital

• Lucca Michael

  Department Of Education & Research St Mary's Duluth Clinic Regional Heart Center

• Gilchrist Ian

  Heart & Vascular Institute Milton S Hershey Medical Center

• Bertolet Barry

  Cardiology Associates Of North Mississippi North Mississippi Medical Center

• Yakubov Steven

  Ohio Health Research Institute Riverside Methodist Hospital

• Ormiston John

  Mercy Angiography Unit Mercy Hospital

• O'shaughnessy Charles

  North Ohio Research Elyria Memorial Hospital

• Worthley Stephen

  University Of Adelaide Royal Adelaide Hospital

関連論文

• OE-096 Routine Angiographic Follow-up : More Repeat Revascularization, but No Long-Term Benefit(OE17,Coronary Revascularization, PCI (Restenosis/Others/DES) (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation S
• 1 Optimal Revascularization Strategies in Patients with Total Occlusions : 1-year Results from the SYNTAX Trial(Late Breaking Clinical Trials II,The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• Long-Term Benefit of the TAXUS Liberte Stent in Small Vessels and Long Lesions : TAXUS ATLAS Program

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