細胞内遺伝子発現制御を目指した遣伝子に対するピンポイント反応の開発

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概要

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• The site-specific reaction with high efficiency and specificity to DNA or RNA has become of great interests, as such modification may have possibility to induce point mutation of a genetic code. The cross-linking reagents within complementary duplexes and triplexes are one of the tools for site-specific modification by forming covalently bond. However, the existing alkylating agents still need further improvement for application in either in vitro or in vivo study. Previously, we have designed a new cross-linking motif, 2-amino-6-vinylpurine(1), toward cytosine by expecting a proximity effect within the complex resembling a natural G-C pair. In this paper, we wish to describe the development of the novel cross-linking reagents based on the structure of 1.

• 2011-02-01

著者

• 永次 史

  東北大学多元物質科学研究所

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• ポストゲノム時代における有機化学の役割(ベランダ,ポストゲノム時代の有機化学)
• 細胞内遺伝子発現制御を目指した遣伝子に対するピンポイント反応の開発

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