Cordycepin Prevents Hyperlipidemia in Hamsters Fed a High-Fat Diet via Activation of AMP-Activated Protein Kinase
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概要
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Hyperlipidemia is a major risk factor for cardiovascular diseases. In this study, we investigated the potential effects of cordycepin (3′-deoxyadenosine), a bioactive component of the fungus Cordyceps militaris, on hyperlipidemia. We found that in male Syrian golden hamsters fed a high-fat diet (HFD), daily administration of cordycepin effectively reduced the accumulation of serum total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-c) and suppressed HFD-associated increases in relative retroperitoneal fat. It also increased the levels of phospho–AMP-activated protein kinase (AMPK) and phospho–acetyl-CoA carboxylase (phospho-ACC) in liver and retroperitoneal adipose tissues. In HepG2 cells, cordycepin stimulated robust concentration- and time-dependent AMPK activation that correlated with the activation of ACC and the suppression of lipid biosynthesis. However, pretreatment with compound C, a specific inhibitor of AMPK, substantially abolished the effects of cordycepin on AMPK activation and lipid biosynthesis inhibition. These results indicate that cordycepin prevents hyperlipidemia via activation of AMPK. Experiments on abnormal metabolic mice indicated that cordycepin can also improve insulin sensitivity effectively.
- 2010-08-20
著者
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Wu Cheng-ai
Department of Molecular Orthopaedics, Beijing Institute of Traumatology and Orthopaedics, China
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Zhu Hai-bo
Key Laboratory Of Natural Drugs Biosynthesis Ministry Of Health & Key Laboratory Of Bioactive Su
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Gao Jian
Key Laboratory Of Natural Drugs Biosynthesis Ministry Of Health & Key Laboratory Of Bioactive Su
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Guo Peng
Pharmacolog And Toxicology Research Center Institute Of Medicinal Plant Development Chinese Academy
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Lian Ze-qin
Key Laboratory Of Natural Drugs Biosynthesis Ministry Of Health & Key Laboratory Of Bioactive Su
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Kai Qu
Key Laboratory Of Natural Drugs Biosynthesis Ministry Of Health & Key Laboratory Of Bioactive Su
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Wu Chong-ming
Protein Science Laboratory Of Ministry Of Education School Of Life Sciences Tsinghua University
関連論文
- Cordycepin Prevents Hyperlipidemia in Hamsters Fed a High-Fat Diet via Activation of AMP-Activated Protein Kinase
- Hyperlipidemic Guinea Pig Model: Mechanisms of Triglyceride Metabolism Disorder and Comparison to Rat
- Cordycepin Prevents Hyperlipidemia in Hamsters Fed a High-Fat Diet via Activation of AMP-Activated Protein Kinase