Identification of a Spatio-Temporal Enhancer Element for the Alzheimer's Amyloid Precursor Protein-Like-1 Gene in the Nematode Caenorhabditis elegans

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概要

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• During the larva-to-adult transition of the nematode Caenorhabditis elegans, expression of the Alzheimer’s amyloid precursor protein-like gene, apl-1, is temporally regulated in seam cells. This regulation requires several transcription factors, including nuclear receptor NHR-25. Here we describe a critical cis-regulatory element of apl-1 transcription. The element is conserved among Caenorhabditis sister species and is similar to nuclear receptor binding consensus.

• 2010-12-23

著者

• Niwa Ryusuke

  Initiative For The Promotion Of Young Scientists' Independent Res. Graduate School Of Life And

• Niwa Ryusuke

  Initiative For The Promotion Of Young Scientists' Independent Research Graduate School Of Life

• Hada Kazumasa

  Initiative For The Promotion Of Young Scientists' Independent Research Graduate School Of Life

関連論文

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• Identification of a Spatio-Temporal Enhancer Element for the Alzheimer's Amyloid Precursor Protein-Like-1 Gene in the Nematode Caenorhabditis elegans

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