Preparation of Protein Transduction Domain-Fused Peptidyl Prolyl cis/trans Isomerase Pin1
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概要
- 論文の詳細を見る
The phenotypes of mice lacking peptidyl prolyl cis/trans isomerase Pin1 (Pin1−⁄−) indicated that deficient Pin1 might be related to a variety of diseases. We created TAT-Pin1, a fusion protein of human immunodeficiency virus 1 trans-activator of transcription factor with Pin1. Treatment of HeLa cells with TAT-Pin1 increased the ratio of the S phase. Moreover, TAT-Pin1 restored the proliferating function of Pin1−⁄− mouse embryonic fibroblasts which cannot restart proliferation after G0 arrest. These results indicate that TAT-Pin1 is useful in studying the functions of Pin1 and can be developed as a macromolecular drug for diseases related to Pin1 loss.
- 社団法人 日本農芸化学会の論文
- 2010-10-23
著者
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Uchida Takafumi
Molecular Enrymology Department Of Molecular Cell Science Graduate School Of Agricultural Science To
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Hidaka Masafumi
Molecular Enrymology Department Of Molecular Cell Science Graduate School Of Agricultural Science To
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Ohashi Tsubasa
Molecular Enrymology Department Of Molecular Cell Science Graduate School Of Agricultural Science To
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Teshima Sumito
Molecular Enrymology Department Of Molecular Cell Science Graduate School Of Agricultural Science To
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