Cilostazol Ameliorates Nephropathy in Type 1 Diabetic Rats Involving Improvement in Oxidative Stress and Regulation of TGF-β and NF-κB
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概要
- 論文の詳細を見る
Diabetic nephropathy is characterized as the progressive development of renal insufficiency in a setting of hyperglycemia. Previous studies indicate that reactive oxygen species (ROS) play an important role in high glucose-induced renal injury. Cilostazol was reported to lower the production of superoxide significantly in situ. We hypothesized that cilostazol administration in streptozotocin-induced diabetic rats exerts effects via improving oxidative stress. Male Sprague–Dawley rats were fed with cilostazol (5 mg/kg or 25 mg/kg) for 12 weeks after streptozotocin-induced diabetes mellitus. The results showed that cilostazol decreased reactive oxygen species activity significantly in the kidneys of diabetic rats and improved the urine albumin/creatinine ratio. Cilostazol can also improve the levels of serum cholesterol, triglyceride, and LDL-cholesterol. Additionally, diabetes-caused increased glomerular size, TGF-β, and NF-κB decreased under treatment with cilostazol in diabetic rats. Our results indicate that cilostazol has beneficial effects in early diabetic nephropathy.
- 2010-07-23
著者
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Lee Wen-chin
Division Of Nephrology Department Of Internal Medicine Chang Gung Memorial Hospital-kaohsiung Medica
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Wang John
Department Of Pathology Taichung Veterans General Hospital
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Lee Huei-jane
Institute Of Biochemistry And Biotechnology College Of Medicine Chung Shan Medical University
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Lin Pei-ying
Institute Of Biochemistry And Biotechnology Medical College Chung Shan Medical University
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Lee Wen-chin
Division Of Nephrology Department Of Internal Medicine Show Chwan Memorial Hospital
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Wen Mei-chin
Department Of Pathology Taichung Veterans General Hospital
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CHEN Hong-Chen
Department of Life Sciences, National Chung Hsing University
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WANG Chih-Ying
Institute of Biochemistry and Biotechnology, Medical College, Chung Shan Medical University
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OU Tin-Tsz
Institute of Biochemistry and Biotechnology, Medical College, Chung Shan Medical University
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CHEN Chen-Chang
Department of Pathology, Taichung Veterans General Hospital
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Ou Tin-tsz
Institute Of Biochemistry And Biotechnology Medical College Chung Shan Medical University
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Chen Hong-chen
Department Of Life Sciences National Chung Hsing University
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Wang Chih-ying
Institute Of Biochemistry And Biotechnology Medical College Chung Shan Medical University
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Chen Chen-chang
Department Of Pathology Taichung Veterans General Hospital
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WEN Mei-Chin
Department of Pathology and Laboratory Medicine, Taichung Veteran General Hospital
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WANG John
Department of Pathology and Laboratory Medicine, Taichung Veteran General Hospital
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