Evaluation of the Protective Effects of Chinese Herbs against Biomolecule Damage Induced by Peroxynitrite

概要

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This work evaluates the protective effects of Chinese herbs against ONOO−-induced biomolecule damage. Thirty-two Chinese traditional herbs were preliminarily screened for their ONOO−-scavenging activity by the fluorometric method. The potency of scavenging activity was in the following order: Apis cerana Fabricius (Propolis) > Rosmarinus officinalis L (Rosemary) > Pseudolarix amabilis (Nelson) Rehd. (Pine Bark PE) > Echinacea Moenck. (Echinacea); the remaining twenty-eight herbs performed unsatisfactorily for their scavenging activity. The four extracts with high ONOO− scavenging activity were selected for further characterization of their inhibiting effects on DNA single breaks, tyrosine nitration and LDL oxidation. A further study of the origin of this scavenging activity on the major active components showed cichoric acid and rosemary acid to both have strong ability to scavenge ONOO−. These scavengers might be developed as therapeutic drugs for preventing ONOO−-involved diseases.
2010-07-23