Synthesis and Anticancer Evaluation of Naphthoquinone Esters with 2'-Cyclopentyl and 2'-Cyclohexyl Substituents
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概要
- 論文の詳細を見る
Twelve novel naphthoquinone esters containing cyclopentyl and cyclohexyl substituents at C-2′ of the propyl chain were synthesized by starting from 1-hydroxy-2-naphthoic acid via alkylation with cyclopentyl ester and cyclohexyl ester. They were evaluated for cytotoxicity against three cancer cell lines (human epidermoid carcinoma (KB), human cervical carcinoma (HeLa), and human hepatocellular carcinoma (HepG2)). In comparison to naphthoquinone esters with the 2′,2′-dimethyl group, the naphthoquinones with a 2′-cyclopentyl substituent showed stronger activity than those with a 2′-cyclohexyl substituent, but less than that with the 2′,2′-dimethyl group. This work provides new information about the effect of 2′-position substituents on the cytotoxicity of naphthoquinone ester analogues.
- 社団法人 日本農芸化学会の論文
- 2010-06-23
著者
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Hasitapan Komkrit
Natural Products And Organic Synthesis Res. Unit (npos) Dep. Of Chemistry And Center For Innovation
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Hasitapan Komkrit
Natural Products And Organic Synthesis Research Unit (npos) Department Of Chemistry And Center For I
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Kongkathip Ngampong
Natural Products And Organic Synthesis Res. Unit (npos) Dep. Of Chemistry And Center For Innovation
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Kongkathip Ngampong
Natural Products And Organic Synthesis Research Unit (npos) Department Of Chemistry And Center For I
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PRADIDPHOL Narathip
Natural Products and Organic Synthesis Research Unit (NPOS), Department of Chemistry and Center for
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KPNGKATHIP Boonsong
Natural Products and Organic Synthesis Research Unit (NPOS), Department of Chemistry and Center for
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Pradidphol Narathip
Natural Products And Organic Synthesis Research Unit (npos) Department Of Chemistry And Center For I
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Kpngkathip Boonsong
Natural Products And Organic Synthesis Research Unit (npos) Department Of Chemistry And Center For I
関連論文
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- Synthesis and Anticancer Evaluation of Naphthoquinone Esters with 2'-Cyclopentyl and 2'-Cyclohexyl Substituents