The Adenovirus-Mediated Transfer of PTEN Inhibits the Growth of Esophageal Cancer Cells in Vitro and in Vivo

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概要

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• The development and progression of esophageal cancer is associated with multiple alterations in the genome, including loss of the tumor suppressor phosphatase and tensin homolog deleted from the chromosome 10 (PTEN) gene. The purpose of this study was to determine the effects of adenovirus-mediated MMAC/PTEN expression on the growth and survival of human esophageal cancer cells in vitro and in vivo. We found that compared to control cells, overexpression of PTEN significantly suppressed growth and induced apoptosis in esophageal cancer cell lines Eca-109 and TE-1 via downregulation of Bcl-2 expression and changes in cell-cycle progression. Adenovirus PTEN also inhibited the growth of subcutaneous tumor xenografts by significantly reducing tumor size in vivo. Thus our results confirm the proposed functional role of MMAC/PTEN as a regulator of esophageal cancer progression in vivo and in vitro. PTEN might be an important biological marker and potential therapeutic target in the treatment of human esophageal cancer.

• 2010-04-23

著者

• Zhou Yong-an

  Department of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University

• Zhao Jin-bo

  Department of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University

• WANG Xiao-ping

  Department of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University

• JIANG Tao

  Department of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University

• GU Zhong-ping

  Department of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University

• WANG Xian-ni

  Department of Neurology, Tangdu Hospital, Fourth Military Medical University

• LI Xiao-fei

  Department of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University

• Li Xiao-fei

  Dep. Of Thoracic Surgery Tangdu Hospital Fourth Military Medical Univ.

• Wang Xian-ni

  Dep. Of Neurology Tangdu Hospital Fourth Military Medical Univ.

• Jiang Tao

  Department Of Computing Science University Of California Riverside

• Gu Zhong-ping

  Dep. Of Thoracic Surgery Tangdu Hospital Fourth Military Medical Univ.

• Wang Xiao-ping

  Department Of Nutrition And Food Hygiene School Of Radiation Medicine And Public Health Medical Coll

• Zhang Tao

  Department Of Advanced Systems Control Engineering Graduate School Of Science And Engineering Saga U

• Zhang Tao

  Department Of Thoracic Surgery Tangdu Hospital Fourth Military Medical University

• Li Xiao-fei

  Department Of Thoracic Surgery Tangdu Hospital Fourth Military Medical University

• Gu Zhong-ping

  Department Of Thoracic Surgery Tangdu Hospital Fourth Military Medical University

• Zhou Yong-an

  Department Of Thoracic Surgery Tangdu Hospital Fourth Military Medical University

• Jiang Tao

  Department Of Thoracic Surgery Tangdu Hospital Fourth Military Medical University

• Zhao Jin-bo

  Department Of Thoracic Surgery Tangdu Hospital Fourth Military Medical University

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