F-Box Proteins That Contain Sugar-Binding Domains

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概要

• 論文の詳細を見る

• F-box proteins are the substrate-recognition subunits of the SCF (Skp1-Cul1-F-box protein) complex, which is the largest known class of E3 ubiquitin ligases. They play important roles in ubiquitin-dependent proteolysis in eukaryotes. The human genome contains about 70 genes for F-box proteins, and at least five homologous F-box proteins containing a conserved motif in their C-termini are thought to recognize sugar chain of N-linked glycoproteins. Among theses, Fbs1 and Fbs2 are perhaps involved in the endoplasmic reticulum-associated degradation pathway. In this review, I focus on the in vivo function of Fbs1 and homologous proteins, novel intracellular oligosaccharide recognition molecules involved in the quality control system.

• 社団法人 日本農芸化学会の論文
• 2007-11-23

著者

• YOSHIDA Yukiko

  Laboratory of Frontier Science, The Tokyo Metropolitan Institute of Medical Science

• Yoshida Yukiko

  Laboratory Of Frontier Science The Tokyo Metropolitan Institute Of Medical Science

関連論文

• F-Box Proteins That Contain Sugar-Binding Domains
• F-Box Proteins That Contain Sugar-Binding Domains
• A Novel Role for N-Glycans in the ERAD System

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