Bilirubin Is Negatively Associated With Hemoglobin A_<1c> Independently of Other Cardiovascular Risk Factors in Apparently Healthy Japanese Men and Women
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概要
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Background: Serum total bilirubin (TB) is a potent antioxidant and may be a negative risk factor of cardiovascular disease. In non-diabetic adults, hemoglobin A1c (HbA1c), but not fasting plasma glucose, is an independent risk factor of cardiovascular disease. Methods and Results: Linear regression using TB as a dependent variable and cardiovascular risk factors, including HbA1c, as independent variables, linear regression using HbA1c as a dependent variable and other cardiovascular risk factors, including TB, as independent variables, and logistic regression using the highest decile (≥5.4%) of HbA1c as a dependent variable and TB and other cardiovascular risk factors as independent variables were performed for 893 apparently healthy male smokers, 1,607 male nonsmokers, and 1,680 women. The standardized regression coefficient of HbA1c for TB and that of TB for HbA1c was -0.12 (P=0.007) and -0.06 (P=0.02), respectively, in the smokers, -0.20 (P<0.0001) and -0.07 (P<0.0001), respectively, in the nonsmokers, and -0.21 (P<0.0001) and -0.14 (P<0.0001), respectively, in the women. The odds ratio of 1 SD increment in TB for HbA1c ≥5.4% was not significant in the smokers, 0.67 (P=0.002) in the nonsmokers, and 0.55 (P<0.0001) in the women. Conclusions: Bilirubin was negatively associated with HbA1c independently of other cardiovascular risk factors in apparently healthy Japanese men and women. The association was weak in male smokers. (Circ J 2011; 75: 190-195)
- 社団法人 日本循環器学会の論文
- 2010-12-25
著者
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Oda Eiji
Medical Check-up Center Tachikawa Medical Center
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Kawai Ryu
Medical Check-up Center Tachikawa Medical Center
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