Concurrent Chemoradiotherapy with S-1 as First-line Treatment for Patients with Oropharyngeal Cancer
スポンサーリンク
概要
- 論文の詳細を見る
Purpose: S-1 is an oral fluoropyrimidine. The purpose of this study was to review the clinical outcomes of S-1 with concurrent radiotherapy for patients with oropharyngeal cancer. Materials and Methods: Between 2002 and 2007, 38 patients with oropharyngeal cancer treated concurrently with S-1 and definitive radiotherapy were reviewed. The clinical stage was Stage I in 4 patients, Stage II in 7, Stage III in 7, and Stage IV in 20. S-1 was administered orally twice daily for 4 consecutive weeks followed by a 2-week drug withdrawal. The initial dose of S-1 was 65 mg/m2/day. All patients were treated using three-dimensional conformal radiotherapy with a median total dose of 65.1 Gy (range, 60.0–71.0 Gy). Clinical outcomes and major acute toxicities were analyzed based on medical records and clinical follow-up. Results: With a median follow-up time of 33 months, the 3-year estimates of local-regional control, distant metastases-free survival, disease-free survival, and overall survival for all patients were 75%, 80%, 65%, and 80%, respectively. The 3-year estimates of local-regional control according to stage were 100% for Stages I and II, 86% for Stage III, and 56% for Stage IV. The rate of ≥ Grade 3 acute mucositis was 32%, and the rate of ≥ Grade 3 hematological toxicities was 8%. No other severe toxicities were observed. Conclusions: Concurrent chemoradiotherapy with S-1 was found to be effective, especially for early disease. The treatment-related toxicities were acceptable, and the incidence of myelotoxicity was low. Further study must be carried out to compare with other chemotherapy regimens.
- Journal of Radiation Research 編集委員会の論文
- 2011-01-16
著者
-
HONDA Hiroshi
Department of Physics, Faculty of Science, Shinshu University
-
Shioyama Yoshiyuki
Department Of Clinical Radiology Graduate School Of Medical Sciences Kyushu University
-
Shioyama Yoshiyuki
九州大学 医学研究院臨床放射線科学
-
Shioyama Yoshiyuki
九州大学病院別府先進医療センター 放射線科
-
NONOSHITA Takeshi
Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University
-
NAKAMURA Katsumasa
Department of Radiology, Kyushu University Hospital at Beppu
-
NAKASHIMA Torahiko
Department of Otorhinology, Graduate School of Medical Sciences, Kyushu University
-
OHGA Saiji
Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University
-
YOSHITAKE Tadamasa
Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University
-
OHNISHI Kayoko
Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University
-
Ohga Saiji
Department Of Clinical Radiology Graduate School Of Medical Sciences Kyushu University
-
Ohga Saiji
九州大学 医学研究院臨床放射線科学
-
TERASHIMA Kotarou
Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University
-
KOMUNE Shizuo
Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University
-
Honda Hiroshi
Department Of Clinical Radiology Graduate School Of Medical Sciences Kyushu University
-
Nonoshita Takeshi
Department Of Clinical Radiology Graduate School Of Medical Sciences Kyushu University
-
Komune Shizuo
Department Of Otolaryngology Faculty Of Medicine Kyushu University
-
Komune Shizuo
Department Of Otorhinolaryngology Graduate School Of Medical Sciences Kyushu University
-
Honda Hiroshi
Department Of Agricultural Chemistry Tokyo University Of Agriculture
-
Ohnishi Kayoko
Department Of Clinical Radiology Graduate School Of Medical Sciences Kyushu University
-
Nakashima Torahiko
Department Of Clinical Radiology Graduate School Of Medical Sciences Kyushu University
-
Terashima Koutarou
Department Of Clinical Radiology Graduate School Of Medical Sciences Kyushu University
-
Toh Yasushi
Department Of Clinical Radiology Graduate School Of Medical Sciences Kyushu University
-
Nakamura Katsumasa
Department Of Radiology Kyushu University Hospital At Beppu
-
Honda Hiroshi
Department Of Clinical Radiology Kyushu University
-
Nakashima Torahiko
Department Of Otorhinolaryngology Graduate School Of Medical Sciences Kyushu University
-
Toh Yasushi
Department Of Clinical Radiology Kyushu University
-
Yoshitake Tadamasa
Department Of Clinical Radiology Graduate School Of Medical Sciences Kyushu University
-
Yoshitake Tadamasa
九州大学 医学系学府臨床放射線科学
-
Nakamura Katsumasa
Department Of Radiology Faculty Of Medicine Kyushu University
-
Nakamura Katsumasa
Department Of Clinical Radiology Graduate School Of Medical Sciences Kyushu University
関連論文
- Nuclear Magnetic Resonance of Ce(Co_Fe_x)_4B (0 ≤ x ≤ 0.20)
- Retroperitoneal well-differentiated inflammatory liposarcoma : a diagnostic dilemma
- Hepatocellular carcinoma with a prominent vascular scar in the center : MR imaging findings
- Concurrent Chemoradiotherapy with S-1 for T2N0 Glottic Squamous Cell Carcinoma
- Concurrent Chemoradiotherapy with S-1 as First-line Treatment for Patients with Oropharyngeal Cancer
- Explanation for the failure of neoadjuvant chemotherapy to improve outcomes after radiotherapy for locally advanced uterine cervical cancer from the standpoint of the tumor regression rate
- A Simplified Method of T1ρ Mapping in Clinical Assessment of Knee Joint
- Bilirubin potentiates inhibitory synaptic transmission in lateral superior olive neurons of the rat
- Extraosseous accumulation of ^Tc-HMDP to radiation nephropathy, mimicking recurrent neuroblastoma
- Alterations of tumor suppressor genes (Rb, p16, p27 and p53) and an increased FDG uptake in lung cancer
- Quantitative Perfusion Imaging with Pulsed Arterial Spin Labeling : A Phantom Study
- A Method to Reduce Saline and Heparin in Intraoperative Cerebral Angiography : A Preliminary Report
- Comparison of ^FDG-PET with ^Tc-HMDP scintigraphy for the detection of bone metastases in patients with breast cancer
- PET evaluation of the relationship between D_2 receptor binding and glucose metabolism in patients with parkinsonism
- Lesion detectability of a gamma camera based coincidence system with FDG in patients with malignant tumors : A comparison with dedicated positron emission tomography
- An analysis of the physiological FDG uptake pattern in the stomach
- Differential FDG accumulation associated with GLUT-1 expression in a patient with lymphoma
- Clinical impact of whole body FDG-PET on the staging and therapeutic decision making for malignant lymphoma
- Importance of the lateral anatomic tibial slope as a guide to the tibial cut in total knee arthroplasty in Japanese patients
- Abdominal Surgery for Patients on Maintenance Hemodialysis
- Chemoradiation for Small Cell Esophageal Carcinoma : Report of 11 Cases from Multi-institution Experience
- Predictive Factors of Esophageal Stenosis Associated with Tumor Regression in Radiation Therapy for Locally Advanced Esophageal Cancer
- Breath-hold monitoring and visual feedback for radiotherapy using a charge-coupled device camera and a head-mounted display : system development and feasibility
- High-dose-rate brachytherapy for previously irradiated patients with recurrent esophageal cancer
- Erythema multiforme and Stevens-Johnson syndrome following radiotherapy
- Long-term local control of recurrent adenoid cystic carcinoma in the parotid gland with radiotherapy and intraarterial infusion chemotherapy
- Stage I and II Non-Hodgkin's Lymphoma : Results of Combined of THP-COP Chemotherapy and Radiotherapy
- Radical external beam radiotherapy for prostate cancer in Japan : differences in the patterns of care among Japan, Germany, and the United States
- Different Mutation Frequencies and Spectra among Organs by N-Melthyl-N-nitrosourea in rpsL (strA) Transgenic Mice
- Corrugated Fiberboard as a Positioning Insert for Patients Undergoing Radiotherapy
- MR Imaging of Renal Cell Carcinoma : Its Role in Determining Cell Type
- Optimal Multi-phase Three-dimensional Fast Imaging with Steady-state Free Precession Dynamic MRI and Its Clinical Application to the Diagnosis of Hepatocellular Carcinoma
- Recent developments in imaging diagnostics for HCC : CT arteriography and CT arterioportography evaluation of vascular changes in premalignant and malignant hepatic nodules
- MR Imaging of Focal Nodular Hyperplasia of he Liver: Value of Contrast-Enhanced Dynamic Study
- Hepatocellular Carcinoma with Pyrexia : Report of a Case
- Well - differentiated Hepatocellular Carcinoma : Isointense to Liver Parenchyma on Superparamagnetic Iron Oxide - Enhanced MR
- SPECT evaluation of cerebral blood flow during arm exercise in patients with subclavian steal
- Apparent Diffusion Coefficients of Breast Tumors : Clinical Application
- Circumscribed Mass Lesions on Mammography : Dynamic Contrast-Enhanced MR Imaging to Differentiate Malignancy and Benignancy
- Choledochocele associated with superficial spreading cancer with cholesterolosis of the bile duct
- Chromosomal FISH analysis of unfertilized human oocytes and polar bodies
- IS-99 Quantitative Analysis of Fetal DNA in Maternal Serum in Normal and Aneuploid Pregnancies
- A Phenotypically Normal Liveborn Male after Prenatal Diagnosis of Trisomy 20 Mosaicism
- Small bowel perforation resulting from blunt abdominal trauma : interval change of radiological characteristics
- Obesity affects expression of progesterone receptors and node metastasis of mammary carcinomas in postmenopausal women without a family history
- Classical tandem-source dwelling covering the entire uterus : essential in modern intracavitary radiotherapy for cervical cancer?
- Alcohol drinking, cigarette smoking, and the development of squamous cell carcinoma of the esophagus : epidemiology, clinical findings, and prevention
- The Triangulating Stapling Technique for Cervical Esophagogastric Anastomosis After Esophagectomy
- Pathogenicity of Glycoprotein C-Deficient Herpes Simplex Virus 1 Strain TN-1 Which Encodes Truncated Glycoprotein C
- Detachment and replacement of externa and larval release of Sacculina polygenea
- Management of Nodular Goiters and Their Operative Indications
- GABA-induced response in spiral ganglion cells acutely isolated from guinea pig cochlea
- Alcohol drinking, cigarette smoking, and the development of squamous cell carcinoma of the esophagus : molecular mechanisms of carcinogenesis
- Suppression of Drift Waves in an Ion Beam-Plasma System
- Effect of Passive Muscle Length Change on Apparent Diffusion Coefficient : Detection with Clinical MR Imaging
- Attractant for Rice Weevil, Sitophilus zeamais MOTSCHULSKY (Coleoptera : Rhynchophoridae), from Rice Grains : II. Fractionation of Rice Grains and the Nature of the Crude Attractive Fraction
- Attractant for Rice Weevil, Sitophilus zeamais MOTSCHULSKY (Coleoptera : Rhynchophoridae), from Rice Grains : I Bioassay Method for the Attractancy of Rice Grains to Rice Weevils
- Chordoma of cervical vertebra protruding into the oral cavity
- Relapse patterns of localized non-Hodgkin's lymphoma of the head and neck after clinical remission: results of a strict follow-up procedure
- Relapsed Non-Hodgkin's Lymphoma: Detection and Treatment
- Radiotherapy for Localized Relapse in Patients with Non-Hodgkin's Lymphoma:A Preliminary Report
- FDG-PET in infectious lesions: The detection and assessment of lesion activity
- Prediction of Local Failures with a Combination of Pretreatment Tumor Volume and Apparent Diffusion Coefficient in Patients Treated with Definitive Radiotherapy for Hypopharyngeal or Oropharyngeal Squamous Cell Carcinoma
- Cancer Patients’ Morbidity (III) : Malnutrition in Relation to Doctors’, Nurses’ and Patients’ Personality
- Concurrent Chemoradiotherapy with S-1 as First-line Treatment for Patients with Oropharyngeal Cancer
- Superdrainage of the Ileocolic Vein to the Internal Jugular Vein Interposed by an Inferior Mesenteric Vein Graft in Replacing the Esophagus with the Right Hemicolon
- A Simplified Method of T_ Mapping in Clinical Assessment of Knee Joint
- Predictive Factors of Esophageal Stenosis Associated with Tumor Regression in Radiation Therapy for Locally Advanced Esophageal Cancer
- A Case of Lung Cancer with Chest Wall Invasion Showed a Pathologically Complete Response to Preoperative Thermo-chemo-radiotherapy
- Ifi202, an IFN-inducible candidate gene for lupus susceptibility in NZB/W F1 mice, is a positive regulator for NF-κB activation in dendritic cells
- Inflammatory pseudotumor of the liver : Radiologic diagnosis
- Histochemical localization of the extracellular matrix components in the annular ligament of rat stapediovestibular joint with special reference to fibrillin, 36-kDa microfibril-associated glycoprotein (MAGP-36), and hyaluronic acid
- IIB-19 Ultrastructure and histocytochemistry of the rat stapediovestibular joint(THE 46TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- Histochemical Characterization of the Rat Ossicular Joint Cartilage with a Special Reference to Stapediovestibular Joint
- Prediction of Local Failures with a Combination of Pretreatment Tumor Volume and Apparent Diffusion Coefficient in Patients Treated with Definitive Radiotherapy for Hypopharyngeal or Oropharyngeal Squamous Cell Carcinoma
- Gastric Cancer in the Reconstructed Gastric Tube After Radical Esophagectomy : A Single-Center Experience
- A case of diffuse-type primary hepatic lymphoma mimicking diffuse hepatocellular carcinoma
- Diagnostic value of serum prostate-specific antigen in hemodialysis patients
- Risk Factors for Early Recurrence After Curative Hepatectomy for Colorectal Liver Metastases
- II-B-27 Immunohistochemistry of rat ossicular joints(THE 45TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- Soft Coagulation, Polyglycolic Acid Felt, and Fibrin Glue for Prevention of Pancreatic Fistula After Distal Pancreatectomy
- Long-Term Survival Following Radical Surgery After Chemotherapy for Esophagogastric Adenocarcinoma with Extensive Lymph Node Metastases : Report of a Case
- A Case of Multiple Squamous Cell Papillomas of the Trachea
- Case Report : A Case of Recurrent Esophageal Cancer Treated with Chemoradiation Combined with Long-term Hyperthermia Treatment
- Ytterbium-based PARACEST Agent : Feasibility of CEST Imaging on a Clinical MR Scanner
- Impact of FDG-PET/CT in the management of lymphoma
- MR Imaging of Focal Medullary Sponge Kidney : Case Report
- Lymph node metastasis from cancer of the esophagogastric junction, and determination of the appropriate nodal dissection
- A Case of Recurrent Esophageal Cancer Treated with Chemoradiation Combined with Long-term Hyperthermia Treatment
- Safe laparoscopic resection of a gastric gastrointestinal stromal tumor close to the esophagogastric junction
- Prediction of true-negative lymph node metastasis in clinical IA non-small cell lung cancer by measuring standardized uptake values on positron emission tomography
- Correlations between Apparent Diffusion Coefficient Values and Prognostic Factors of Breast Cancer
- Decrease in Venous Irritation by Adjusting the Concentration of Injected Bendamustine
- Corrugated Fiberboard as a Positioning Insert for Patients Undergoing Radiotherapy
- Chemoradiation for Small Cell Esophageal Carcinoma: Report of 11 Cases from Multi-institution Experience
- Rate of ligand exchange of tris(acetylacetonato)iron(III) with 2-thenoyltrifluoroacetone in organic solvents.
- Computer-aided Delineation of Lung Tumor Regions in Treatment Planning CT Images and PET/CT Images Using Localized Level Set Approach
- A case of pulmonary choriocarcinoma metastasis with unusual FDG-PET and CT findings : correlation with pathology
- Tumor-to-tumor metastasis : Lung adenocarcinoma metastasizing to a follicular variant of papillary thyroid carcinoma