Orally Administrated Lactobacillus gasseri TMC0356 Inhibits Growth of Tumors Transplanted into Mice
スポンサーリンク
概要
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Lactobacillus gasseri TMC0356 (TMC0356), a probiotic strain originally isolated from the human intestine, was tested for its anti-tumor activities in vivo in murine tumor models. Oral administration of TMC0356 characteristically inhibited the growth of sarcoma S-180 (S-180) and hepatoma H22 (H22) cells, which had been implanted in mice. Serum gamma interferon was significantly enhanced during TMC0356 administration of 1,000 mg/kg in S-180-bearing mice (p<0.01). Serum levels of tumor necrosis factor- α and interleukin-18 were also altered, though these changes were not statistically significant. These results indicate that the anti-tumor effects of TMC0356 might, at least in part, arise from the impact of this bacterium on cell-mediated immunity in host animals.
- 2009-04-01
著者
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He Fang
Takanashi Milk Products Co. Ltd. Kanagawa
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HE Fang
Technical Research Laboratory, Takanashi Milk Products Co., Ltd.
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HIRAMATSU Masaru
Technical Research Laboratory, Takanashi Milk Products Co., Ltd.
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He Fang
Takanashi Milk Products Co. Ltd Kanagawa Jpn
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He Fang
Technical Research Laboratory Takanashi Milk Products Co. Ltd.
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KAWASE Manabu
Technical Research Laboratory, Takanashi Milk Products Co., Ltd.
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WANG Qi
College of Chinese Medicinal Materials, Jilin Agricultural University
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PAN Jingzhi
College of Chinese Medicinal Materials, Jilin Agricultural University
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Kawase Manabu
Technical Research Laboratory Takanashi Milk Products Co. Ltd.
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Pan Jingzhi
College Of Chinese Medicinal Materials Jilin Agricultural University
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Wang Qi
College Of Chinese Medicinal Materials Jilin Agricultural University
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Hiramatsu Masaru
Technical Research Laboratory Takanashi Milk Products Co. Ltd.
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Kawase Manabu
Technical Research Laboratory, Takanashi Milk Products Co. Ltd.
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KAWASE Manabu
Technical Research Laboratory, Takanashi Milk Products
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