Hodgkin-Huxley Model-Based Analysis of Electric-Field Effect on Nerve Cell Using Self-Organizing Map

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概要

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• This paper describes an analysis of the effects of electric field on nerve cells by using the Hodgkin-Huxley model. When evaluating our model, which combines an additional ionic current source and generated membrane potential, we derive the peak-to-peak value, the accumulated square of variation, and Kolmogorov-Sinai (KS) entropy of the cell-membrane potential excited by 10, 100, 1k, and 10kHz-sinusoidal electric fields. In addition, to obtain a comprehensive view of the time-variation patterns of our model, we used a self-organizing map, which provides a way to map high-dimensional data onto a low-dimensional domain. Simulation results confirmed that lower-frequency electric fields tended to increase fluctuations of the cell-membrane potential, and the additional ionic current source was a more dominant factor for fluctuations of the cell-membrane potential. On the basis of our model, we visually confirmed that the obtained data could be projected onto the map in accordance with responses of cell-membrane potential excited by electric fields, resulting in a combined depiction of the effects of KS entropy and other parameters.

• （社）電子情報通信学会の論文
• 2009-06-01

著者

• Murakawa Kazuo

  Ntt Global Business Strategy Office Ntt Corporation

• MASUGI Masao

  NTT Energy and Environment Systems Laboratories, NTT Corporation

• Masugi Masao

  Ntt Energy And Environment Systems Laboratories Ntt Corporation

関連論文

• Hodgkin-Huxley Model-Based Analysis of Electric-Field Effect on Nerve Cell Using Self-Organizing Map
• A Two-Dimensional Clustering Approach to the Analysis of Audible Noises Induced at Telephone Terminals(Electromagnetic Compatibility (EMC))

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