Effects of Gadolinium-ethoxybenzyl-diethylenetriamine Pentaacetic Acid on T_2-weighted MRCP
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概要
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Purpose: Gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) is a recently developed liver-specific contrast agent for magnetic resonance (MR) imaging that is excreted equally via the kidneys and the biliary system. To our knowledge, its effects on T2-weighted MR cholangiopancreatography (MRCP) images have not been explored. Acquisition of the hepatobiliary phase is recommended 20 min after administration of Gd-EOB-DTPA. Examination time cannot be extended if the contrast does not take effect on T2-weighted MRCP within 20 min after administration. We attempted to assess the change in signal of T2-weighted MRCP by excretion of Gd-EOB-DTPA. Methods: Between March and July 2008, 40 patients (15 women, 25 men; mean age 70.8 years) were examined with abdominal MR imaging. T2-weighted MRCP was performed before and 10 and 20 min after administration of Gd-EOB-DTPA. We analyzed signal intensity of the bile duct, gallbladder, cystic duct, and pancreatic duct on MRCP for changes in intensity. Results: T2-weighted MRCP 20 min after contrast administration showed loss of signal of the bile duct (intrahepatic bile duct in all cases, upper extrahepatic duct in 36 [90%], middle extrahepatic duct in 33 [85%], and lower extrahepatic duct in 26 [67%]), the gallbladder in 23 cases (72%), and the cystic duct in 25 (64%). This signal change increased with time. We observed no change in signal of the pancreatic duct. Conclusion: T2-weighted MRCP sequences should not be obtained after administration of Gd-EOB-DTPA because this contrast agent decreases signal intensity of the biliary structure on these images.
- 2009-12-01
著者
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Saito Tomoko
Department Of Orthopaedic Surgery Graduate School Of Medicine Chiba University
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NAKAMURA Yuko
Department of Radiology, Hiroshima City Hospital
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Ito Katsuhide
Department Of Radiology Hiroshima University
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Saito Tomoko
Department Of Radiology Kure City Medical Association Hospital
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Ito Katsuhide
Department Of Radiology Ja Onomichi General Hospital
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Ito Katsuhide
Department Of Physics School Of Science And Engineering Waseda University
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OHMOTO Toshifumi
Department of Radiology, Kure City Medical Association Hospital
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KAJIMA Toshio
Kajima Clinic
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NISHIMARU Eiji
Department of Radiology, Hiroshima University Hospital
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Nishimaru Eiji
Department Of Radiology Hiroshima University Hospital
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Nakamura Yuko
Department Of Biochemistry And Cell Biology National Institute Of Infectious Diseases
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Ohmoto Toshifumi
Department Of Radiology Kure City Medical Association Hospital
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Nakamura Yuko
Department Of Radiology Kure City Medical Association Hospital
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Saito Tomoko
Department Of Bioproduction Yamagata University
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