Artificial Control of Subtype-Specific Platelet-Derived Growth Factor-Receptor Signaling
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概要
- 論文の詳細を見る
Platelet-derived growth factor (PDGF) signaling controls various physiological functions via two receptor subtypes: PDGF receptor (PDGFR) α and PDGFRβ. Nevertheless, our understanding of their roles is limited because of a lack of pharmacological tools to discriminate subtype-specific signaling. We developed a chimeric receptor by combining ligand-binding-domain truncated PDGFRβ with anti-fluorescein single chain antibody, expecting the control of PDGFRβ-specific signaling by oligomerized fluorescein as an artificial agonist. Results show that calcium mobilization, Cdc42 activation, and cell migration were elicited specifically by the artificial ligand in cells expressing the chimeric receptor. Our method is expected to be useful to understand the subtype-specific roles of PDGFRs in various cellular functions.
- 社団法人 日本薬理学会の論文
- 2009-11-20
著者
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Ohta Yusaku
Department Of Neurobiology Graduate School Of Medicine The University Of Tokyo
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NAMIKI Shigeyuki
Department of Chemistry, University of Tsukuba
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HIROSE KENZO
Department of Endocrine Surgery, Tokyo Women's Medical College
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ISA Masayuki
Department of Neurobiology, Graduate School of Medicine, The University of Tokyo
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Isa Masayuki
Department Of Neurobiology Graduate School Of Medicine The University Of Tokyo
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Hirose Kenzo
Department Of Endocrine Surgery Tokyo Women's Medical College
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Hirose Kenzo
Department Of Neurobiology Graduate School Of Medicine The University Of Tokyo
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Namiki Shigeyuki
Department Of Neurobiology Graduate School Of Medicine The University Of Tokyo
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Namiki Shigeyuki
Department Of Chemistry University Of Tsukuba
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