Oral contraceptive administration attenuates endothelium-dependent relaxation in response to histamine but not to acetylcholine in aortic rings of female rats

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概要

• 論文の詳細を見る

• The incidence of vascular disorders is markedly lower in cycling, pre-menopausal women and post-menopausal women receiving estrogen-progestogen therapy than in men or untreated postmenopausal women. Clinical studies demonstrate that estrogen-progestogen therapy in pre-menopausal women is associated with increased arterial vascular risk. However, the mechanism of estrogen-progestogen therapy in arterial vascular complications remain unclear. Therefore, the present study aimed at investigating whether chronic administration of combined oral contraceptive (OC) containing progestogen with androgenic property alters endothelium-dependent relaxation responses of the aorta to histamine and acetylcholine. The experiments have been studied on aortic rings obtained from vehicle-treated and OC-treated female Sprague-Dawley rats. Isometric reactivity of aortic rings was recorded with a strain gauge transducer. The maximum contractile response of the aortic rings to noradrenaline in the OC-treated group was not significantly different from that in the vehicle-treated group. Both acetylcholine and histamine caused relaxation of the noradrenaline pre-contracted aortic rings. The relaxation response to acetylcholine in rings from vehicle-treated and OC-treated rats did not differ significantly, while relaxation response to histamine was significantly attenuated in aortic rings from OC-treated rats. In conclusion, the results from the present study suggest that the increased arterial vascular risk associated with OC administration might involve altered endothelium-dependent relaxation via histaminergic-mediated mechanism, but not via muscarinergic-mediated mechanism.

• 日本平滑筋学会の論文
• 2009-12-01

著者

• Soladoye Ayodele

  Department Of Physiology College Of Health Sciences University Of Ilorin

• OLATUNJI Lawrence

  Department of Physiology, College of Health Sciences, University of Ilorin

• Olatunji Lawrence

  Department Of Physiology College Of Health Sciences University Of Ilorin

関連論文

• Oral contraceptive administration attenuates endothelium-dependent relaxation in response to histamine but not to acetylcholine in aortic rings of female rats

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