Bronchorelaxant property of 'African potato' (Hypoxis hemerocallidea corm) aqueous extract in vitro

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This study was undertaken to investigate the bronchorelaxant effect of Hypoxis hemerocallidea corm (`African potato) aqueous extract (APE) on spasmogen-provoked contractions of guinea-pig isolated tracheal smooth muscle preparations. APE (25-400 mg/ml) relaxed spasmogen (histamine-, carbachol- and potassium-)-induced contractions of the isolated tracheal muscle preparations in a concentration-dependent manner. The relaxant effects of APE on spasmogen-evoked contractions of the tracheal muscle preparations were not altered by bath-applied propranolol (0.1-5.0 μg/ml), which markedly inhibited or completely abolished the relaxant effects of isoprenaline (0.1-5.0 μg/ml). Although the precise mechanism of the bronchorelaxant effect of APE could not be established in the present study, it is unlikely that the herbs aqueous extract stimulates the β2-adrenoceptors present on the bronchial smooth muscles to produce its bronchodilatation. The finding that APE significantly relaxed (P<0.05) histamine-, carbachol- and high potassium ion concentration (K+, 80 mM)-induced contractions of guinea-pig isolated bronchial muscle preparations appears to suggest that the bronchospasmolytic effect of the plants extract is probably not mediated through a specific receptor, but rather, probably mediated via a non-specific bronchospasmolytic mechanism.
2009-10-01