Profiles of Chemical Effects on Cells (pCEC) : a toxicogenomics database with a toxicoinformatics system for risk evaluation and toxicity prediction of environmental chemicals
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概要
- 論文の詳細を見る
Profiles of Chemical Effects on Cells (pCEC) is a toxicogenomics database with a system of classifying chemicals that have effects on human health. This database stores and handles gene expression profiling information and categories of toxicity data. Chemicals are classified according to the specific tissues and cells they affect, the gene expression changes they induce, their toxicity and biological functions in this database system. The pCEC system also analyzes relationships between chemicals and the genes they affect in specific tissues and cells. The reason why we developed pCEC is to support decision-making within the context of environmental regulation. Especially, exposure to environmental chemicals during fetal and newborn development may result in a predisposition to various disorders such as cancer, learning disabilities and allergies later in life. The identification and prediction of hazardous chemicals using limited information are important issues in human health risk management. Therefore, various toxicity information including lethal dose 50 (LD50), toxicity pathways and pathological data were loaded into pCEC. pCEC is also a facility for query, analysis and prediction of unknown toxicochemical reaction pathways and biomarkers which are based on toxicoinformatical data mining approaches. This database is available online at http://project.nies.go.jp/eCA/cgi-bin/index.cgi. The current version of the database has information on the hepatotoxicity, reproductive toxicity and embryotoxicity of chemicals.
- 2010-02-01
著者
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SONE Hideko
Research Center for Environmental Risk, National Institute for Environmental Studies
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OKURA Masahiro
Research Center for Environmental Risk, National Institute for Environmental Studies
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ZAHA Hiroko
Research Center for Environmental Risk, National Institute for Environmental Studies
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FUJIBUCHI Wataru
Advanced Industrial Science and Technology (AIST), Computational Biology Research Center
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TANIGUCHI Takeaki
Mitsubishi Research Institute, Inc., Practice Areas and Industry Sectors
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AKANUMA Hiromi
Research Center for Environmental Risk, National Institute for Environmental Studies
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NAGANO Reiko
Research Center for Environmental Risk, National Institute for Environmental Studies
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OHSAKO Seiichiro
Graduate School and Faculty of Medicine, The University of Tokyo
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YONEMOTO Junzo
Research Center for Environmental Risk, National Institute for Environmental Studies
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Sone Hideko
Research Center For Environmental Risk National Institute For Environmental Studies
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Zaha Hiroko
Research Center For Environmental Risk National Institute For Environmental Studies
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Nagano Reiko
Research Center For Environmental Risk National Institute For Environmental Studies
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Okura Masahiro
Research Center For Environmental Risk National Institute For Environmental Studies
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Akanuma Hiromi
Research Center For Environmental Risk National Institute For Environmental Studies
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Yonemoto Junzo
Nibs Tsukuba:crest Jst
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Yonemoto Junzo
Research Center For Environmental Risk National Institute For Environmental Studies
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Fujibuchi Wataru
Advanced Industrial Science And Technology
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Ohsako Seiichiro
Graduate School And Faculty Of Medicine The University Of Tokyo
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Taniguchi Takeaki
Mitsubishi Research Institute Inc. Practice Areas And Industry Sectors
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Taniguchi Takeaki
Mitsubishi Research Institute Inc.
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Ueoka Katsuhiko
Department Of Surgical Subspecialties National Research Center For Child Health And Development
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