Angiopoietin-Like Proteins : Potential Therapeutic Targets for Metabolic Syndrome and Cardiovascular Disease
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概要
- 論文の詳細を見る
Recent major increases in obesity and related metabolic diseases (known as the metabolic syndrome (MetS)) because of sedentary lifestyles and overnutrition in developed and developing countries, are an exploding medical and social problem. These conditions are associated with increased risk of cardiovascular disease (CVD), the leading cause of death. Thus, it is necessary to understand the molecular basis underlying MetS and develop effective preventive and therapeutic approaches against CVD. To date, 7 angiopoietin-like proteins (Angptls) that are structurally similar to angiopoietins have been identified. However, none binds to the angiopoietin receptor, Tie2, or to the closely related Tie1 receptor, suggesting that these ligands function differently from angiopoietins. Some Angptls potently regulate angiogenesis, similar to angiopoietins, whereas others have pleiotropic activity other than angiogenesis and function in lipid and energy metabolism. In this review, we focus on the roles of Angptl2 and Angptl6/angiopoietin-like growth factor (AGF) in the development of MetS and CVD, and discuss the potential for Angptl2 and Angptl6/AGF to function as molecular targets for the prevention and treatment of both conditions. (Circ J 2009; 73: 2192-2197)
- 社団法人 日本循環器学会の論文
- 2009-11-20
著者
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Oike Yuichi
Department of Cell Differentiation Institute of Molecular Enbryology and Genetics, Kumamoto Universi
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Oike Yuichi
Department Of Molecular Genetics Graduate School Of Medical Sciences Kumamoto University
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Oike Yuichi
Department Of Cardiology Japanese Red Cross Kumamoto Hospital
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TABATA Mitsuhisa
Division of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, School of Med
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Tabata Mitsuhisa
Division Of Endocrinology Metabolism And Nephrology Department Of Internal Medicine School Of Medici
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