Repetitive Endocardial Focal Discharges During Ventricular Fibrillation With Prolonged Global Ischemia in Isolated Rabbit Hearts
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概要
- 論文の詳細を見る
Background: Ventricular fibrillation (VF) during prolonged (>5 min) global ischemia (GI) could be due to repetitive endocardial focal discharges (REFDs). This hypothesis was tested in isolated rabbit hearts. Methods and Results: With optical mapping, simultaneous endocardial (left ventricle, LV) and epicardial (both ventricles) activations during VF with prolonged GI were studied (protocol I, 8 hearts). Lugol solution was applied to the LV endocardium in additional 5 hearts after 5-min GI (protocol II). During prolonged GI, sustained VF (>30 s) was successfully induced in 7 protocol I hearts. The dominant frequency of summed optical signals at the LV endocardium was higher than at the epicardium (P<0.05). Mapping data showed that after 5-min GI, REFDs were present in >90% for recording time. There were 18 windows of optical recording showing spontaneous VF termination. In 10, once REFDs ceased, the VF episode terminated immediately. Electrical defibrillation was also performed on 3 hearts. Eight shocks showed early VF recurrence after successful defibrillation. REFDs were consistently involved in the initiation period of recurrence. In protocol II, Lugol subendocardial ablation diminished REFD genesis during re-induced VF. These VF episodes were all non-sustained. Conclusions: REFDs at the LV endocardium were important for both VF maintenance and post-shock recurrence during prolonged GI in this model. (Circ J 2009; 73: 1803-1811)
- 2009-09-20
著者
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LIN Shien-Fong
Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana Univers
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Lin Shien-fong
Krannert Institute Of Cardiology And Division Of Cardiology Department Of Medicine Indiana Universit
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Lin Shien-fong
Krannert Institute Of Cardiology And The Division Of Cardiology Department Of Medicine Indiana Unive
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Hsieh Yu-cheng
Cardiovascular Center Taichung Veterans General Hospital Taichung And Department Of Internal Medicin
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CHIU Yung-Tsung
Department of Medical Research and Education, Taichung Veterans General Hospital
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Chiu Yung-tsung
Department Of Education And Research Taichung Veterans General Hospital
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TING Chih-Tai
Cardiovascular Center, Taichung Veterans General Hospital, Taichung and Department of Internal Medic
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WU Tsu-Juey
Cardiovascular Center, Taichung Veterans General Hospital, Taichung and Department of Internal Medic
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Wu Tsu-juey
Cardiovascular Center Taichung Veterans General Hospital Taichung And Department Of Internal Medicin
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Ting Chih-tai
Cardiovascular Center Taichung Veterans General Hospital Taichung And Department Of Internal Medicin
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Hsieh Yu-cheng
Cardiovascular Center Taichung Veterans General Hospital And Department Of Internal Medicine Faculty
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Wu Tsu-juey
Cardiovascular Center Taichung Veterans General Hospital And Department Of Internal Medicine Faculty
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Ting Chih-tai
Cardiovascular Center Taichung Veterans General Hospital And Department Of Internal Medicine Faculty
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