Endothelial Dysfunction : The First Step Toward Coronary Arteriosclerosis

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概要

• 論文の詳細を見る

• The endothelium causes relaxations of the underlying vascular smooth muscle, by releasing nitric oxide (NO). The endothelial cells also can evoke hyperpolarization of the vascular smooth muscle cells (endothelium-dependent hyperpolarizations, endothelium-derived hyperpolarizing factors-mediated responses). Endothelium-dependent relaxations involve both pertussis toxin-sensitive Gi and pertussis toxin-insensitive Gq coupling proteins. The endothelial release of NO is reduced in diabetes and hypertension. Arteries covered with regenerated endothelium lose the pertussis-toxin sensitive pathway for NO-release. This dysfunction favors vasospasm, thrombosis, penetration of macrophages, cellular growth and the inflammatory reaction leading to atherosclerosis. Endothelial cells also release endothelium-derived contracting factors (EDCF). Most endothelium-dependent contractions are mediated by vasoconstrictor prostanoids (endoperoxides and prostacyclin), which activate thromboxane-prostanoid (TP)-receptors of the underlying vascular smooth muscle cells. EDCF-mediated responses are augmented by aging, hypertension and diabetes. Thus, endothelial dysfunction is the first step toward coronary arteriosclerosis.

• 社団法人　日本循環器学会の論文
• 2009-03-20

著者

• Vanhoutte Paul

  Department Of Pharmacology Li Ka Shing Faculty Of Medicine The University Of Hong Kong

• Vanhoutte Paul

  Deparment Of Pharmacology Faculte Pitie -salpetriaire Universite Paris Vi

関連論文

• Endothelial Control of Vasomotor Function : From Health to Coronary Disease
• Endothelial Control of Cardiovascular Function
• Endothelial Dysfunction : The First Step Toward Coronary Arteriosclerosis

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