Acquisition-weighted MRSI for Detection and Quantification of BNCT ^<10>B-carrier L-p-boronophenylalanine-fructose Complex, a Phantom Study

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概要

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• Proton magnetic resonance spectroscopy (1H MRS) is a potential method to detect and quantify a boron neutron capture therapy 10B-carrier compound, L-p-boronophenylalanine (BPA), in the brain. However, optimal positioning of MRS voxel to capture tissue with maximal BPA concentration can be challenging. Three dimensional proton magnetic resonance spectroscopic imaging (3D 1H MRSI) provides spectral data covering a large spatial volume, which is a major advantage in detecting and quantifying BPA. BPA detection limit in phantom conditions was determined at 1.5 T using a 3D 1H MRSI protocol with clinically acceptable nominal spatial resolution and duration. Quantification tests for aqueous phantom were performed using both single voxel MRS and 3D MRSI. In 3D MRSI, BPA detection limit was ~1.0 mM and BPA quantification accuracy was better than ±5%. The results suggest that MRSI would be a feasible method for in vivo BPA evaluation in clinical conditions.

• 2009-09-16

著者

• Kouri Mauri

  Department Of Oncology Helsinki University Central Hospital

• Heikkinen Sami

  Laboratory Of Organic Chemistry Department Of Chemistry Helsinki University Central Hospital

• TIMONEN Marjut

  Department of Physics, University of Helsinki

• KANKAANRANTA Leena

  Department of Oncology, Helsinki University Central Hospital

• LUNDBOM Nina

  HUS Medical Imaging Center, Helsinki University Central Hospital

• KORTESNIEMI Mika

  HUS Medical Imaging Center, Helsinki University Central Hospital

• SEPPALA Tiina

  Department of Oncology, Helsinki University Central Hospital

• SAVOLAINEN Sauli

  HUS Medical Imaging Center, Helsinki University Central Hospital

• HEIKKINEN Sami

  The Laboratory of Organic Chemistry, University of Helsinki

• Lundbom Nina

  Hus Medical Imaging Center Helsinki University Central Hospital

• Seppala Tiina

  Department Of Oncology Helsinki University Central Hospital

• Timonen Marjut

  Department Of Physics University Of Helsinki

• Savolainen Sauli

  Hus Helsinki Medical Imaging Center Helsinki University Central Hospital

• Kortesniemi Mika

  Hus Medical Imaging Center Helsinki University Central Hospital

• Kankaanranta Leena

  Department Of Oncology Helsinki University Central Hospital

関連論文

• Acquisition-weighted MRSI for Detection and Quantification of BNCT ^B-carrier L-p-boronophenylalanine-fructose Complex, a Phantom Study
• In Vitro Studies on Stability of L-p-boronophenylalanine–fructose Complex (BPA-F)
• In Vitro Studies on Stability of L-ρ-boronophenylalanine-fructose Complex (BPA-F)

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