Spontaneous Erythroid Leukemia in a 6-Wk-Old Male Crlj:B6C3F_1 Mouse
スポンサーリンク
概要
- 論文の詳細を見る
This report describes spontaneous occurrence of erythroid leukemia in a 6 week-old male Crlj:B6C3F1 mouse. Macroscopically, severe hepatosplenomegaly was noted, but no abnormalities were observed in other tissues including the thymus and lymph nodes. Hematological examinations of blood and bone marrow smear preparations revealed marked proliferation of erythroid cells at various stages of maturation, but neither obvious atypia nor neoplastic proliferation of granulocytic cells was observed. Microscopically, there was marked infiltration of neoplastic erythroid cells into the hepatic sinusoids, splenic red pulp, and bone marrow, but there was no infiltration into the thymus or lymph nodes. Corresponding to the hematological findings, no distinct proliferation of granulocytic cells was detected microscopically. Immunohistochemical examination revealed that these cells were positive for hemoglobin. The present case of mouse erythroid leukemia closely resembles "pure erythroid leukemia" in humans.
- 日本毒性病理学会の論文
- 2007-06-30
著者
-
Edamoto Hiroshi
Bozo Research Center Inc.
-
Suwa Kouichi
Bozo Research Center Inc.
-
Tamura Kazutoshi
Bozo Research Center Inc.
-
Suwa Kouichi
Bozo Research Center
関連論文
- N,N-Bis(2-chloroethyl)- N-nitrosourea (BCNU)-induced Apoptosis of Neural Progenitor Cells in the Developing Fetal Rat Brain
- Renal Tubular Cyst Formation in Newborn Rats Treated with p-Cumylphenol
- Changes in blood coagulation-related parameters in phenobarbital-treated rabbits
- 2B-07 The Utility of Alkaline Phosphatase Isozyme Analysis in Rats for Toxicity Studies : Using an ovariectomy model
- 2A-07 A survey of changes in genital organs during adolescence and estrus cycle in female beagles
- Effects of hepatic drug-metabolizing enzyme induction on blood coagulation in rats (2)(Proceedings of the 32nd Annual Meeting)]
- Spontaneous Granular Cell Tumor of Cecum in a Laboratory Beagle
- Spontaneous Erythroid Leukemia in a 6-Wk-Old Male Crlj:B6C3F_1 Mouse
- FRAGMENTATION AND NON-OSMOTIC HEMOLYSIS OF RODENT ERYTHROCYTES
- "P-37 Depletion and repletion of Ca^ induce RBC fragmentation.
- Ultrastructural and Immunohistochemical Studies on Uptake and Distribution of FITC-Conjugated PLGA Nanoparticles Administered Intratracheally in Rats
- Histopathological Changes in the Pancreas from a Spontaneous Hyperglycemic Cynomolgus Monkey
- N,N'-Bis(2-chloroethyl)-N-nitrosourea (BCNU)-induced Apoptosis of Neural Progenitor Cells in the Developing Fetal Rat Brain
- Renal Tubular Cyst Formation in Newborn Rats Treated with p-Cumylphenol