Basic and Translational Research on Proteinase-Activated Receptors : Proteinase-Activated Receptors in Female Reproductive Tissues and Endometriosis
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概要
- 論文の詳細を見る
During the menstrual cycle, dynamic morphological changes are observed in the ovarian follicle and the endometrium. These changes are associated with the onset of the inflammatory response in which many proteinases play various roles. Thrombin-induced activation of PAR1 (proteinase-activated receptor 1) stimulates the production of interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) in human granulosa cells, suggesting a possible role for PAR1 in the ovulatory process. In the endometrium, PAR2 expression increases during the menstrual period. PAR2 activation induces IL-8 production and cell proliferation in human endometrial stromal cells. PAR1 also stimulates proinflammatory cytokine production in human endometrial stromal cells. Thus, the PARs may be important in directing the dynamic changes of the endometrium. PARs also appear to play a role in endometriosis, a common gynecological disease, since activation of PAR1 and PAR2 induces the secretion of inflammatory cytokines and the proliferation of stromal cells in endometriotic lesions. Taken together, PARs appear to play diverse roles in the human reproductive organs.
- 社団法人 日本薬理学会の論文
- 2008-12-20
著者
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TAKETANI Yuji
Department of Obstetrics and Gynecology, University of Tokyo
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OSUGA Yutaka
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo
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Taketani Y
Obstetrics And Gynecology University Of Tokyo
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Taketani Yuji
東京大学 医学系研究科産婦人科
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Osuga Yutaka
東京大学 産婦人科学
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Osuga Y
Obstetrics And Gynecology University Of Tokyo
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Osuga Y
Department Of Obstetrics And Gynecology Graduate School Of Medicine The University Of Tokyo
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Osuga Yutaka
Department Of Obstetrics And Gynecology Faculty Of Medicine The University Of Tokyo
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Osuga Yutaka
東京大学 医学系研究科産婦人科学講座
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Taketani Y
Univ. Tokyo Tokyo
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Taketani Yuji
Department Of Neuropsychiatry Graduate School Of Medicine The University Of Tokyo
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Taketani Yuji
Department Of Obstetrics And Gynecology University Of Tokyo
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Taketani Yuji
Department Of Obstetrics And Gynecology Graduate School Of Medicine University Of Tokyo
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Taketani Yuji
Department Of Obstetrics And Gynecology The University Of Tokyo Hospital
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HIROTA Yasushi
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo
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Hirota Yasushi
Department Of Obstetrics And Gynecology Faculty Of Medicine University Of Tokyo
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