Physiology and Pathophysiology of Proteinase-Activated Receptors (PARs) : Regulation of the Expression of PARs

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概要

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• The level of receptors expressed on the cell surface determines the cellular responsiveness to agonists. Proteinase-activated receptors (PARs) have been reported to be either up-regulated or down-regulated in response to various types of stimulation and pathological situations. In addition, the transcriptional regulation plays a major role in the alteration of the expression of PARs under pathological conditions, while post-translational mechanisms such as phosphorylation, arresting-binding, internalization, and lysosomal degradation, which desensitize activated PARs and terminate intracellular signaling, also play an important role in regulating the expression of PARs and the cellular responsiveness to the agonists. Elucidating the mechanisms related to the expression of PARs is a critical step to understand the pathophysiology of various diseases and establish new therapeutic strategies. However, the molecular mechanism regulating the expression of PARs still remains to be elucidated. This minireview discusses our current understanding of the mechanisms regulating the expression of PARs. The transcription factors and the regulatory elements in the promoter regions, and the proteins that interact with the receptors and thereby regulate their trafficking and desensitization are the main problems that need to be elucidated.

• 社団法人 日本薬理学会の論文
• 2005-01-20

著者

• Hirano Katsuya

  Division of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical

• NISHIMURA Junji

  Division of Clinical Immunology, Department of Immunobiology and Neuroscience, Medical Institute of

• Hirano Katsuya

  Division Of Molecular Cardiology Graduate School Of Medical Sciences Kyushu University

• Nishimura J

  Division Of Molecular Cardiology Research Institute Of Angiocardiology Graduate School Of Medical Sc

• Kanaide Hideo

  Division of Molecular Cardiology, Res. Inst. of Angiocardiol., Fac,of Med., Kyushu Univ.

• Hirano Mayumi

  Division of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical

• YUFU Tatsuya

  Division of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical

• Hirano Katsuya

  Research Institute Of Angiocardiology Faculty Of Medicine Kyushu University

• Yufu Tatsuya

  Division Of Molecular Cardiology Research Institute Of Angiocardiology Graduate School Of Medical Sc

• Kanaide Hideo

  Division Of Molecular Cardiology Res. Inst. Of Angiocardiol. Fac Of Med. Kyushu Univ.

• Hirano Mayumi

  Division Of Molecular Cardiology Research Institute Of Angiocardiology Graduate School Of Medical Sc

• Hirano Mayumi

  Division Of Molecular Cardiology Graduate School Of Medical Sciences Kyushu University

• Hirano Katsunari

  Division Of Molecular Cardiology Research Institute Of Angiocardiology Graduate School Of Medical Sc

• Kanaide Hideo

  International University Of Health And Welfare

• Nishimura Junji

  Division Of Clinical Immunology Department Of Immunobiology And Neuroscience

• Hirano Katsuya

  Division Of Molecular Cardiology Research Institute Of Angiocardiology Graduate School Of Medical Sc

• Kanaide Hideo

  Research Institute Of Angiocardiology And Cardiovascular Clinic Faculty Of Medicine Kyushu Universit

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