多段階質量分析における酸性糖鎖のフラグメンテーション則 : グリコサミノグリカンの配列解析を目指して
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概要
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I focus on the fragmentation rules derived by inspection of the multistage product ion mass spectra of glycosaminoglycan (GAG)-related carbohydrates. To establish a sophisticated sequencing method for GAGs using mass spectrometry, systematic understanding of fragmentation rules is essential. This review proposes an attractive protocol for GAG sequencing based on such knowledge, and shows that multiple-stage mass spectrometry is a powerful and promising technology to decipher highly heterogeneous GAG structures.
- 2009-08-01