The evaluation of control measures against Schistosoma mekongi in Cambodia by a mathematical model
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概要
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<p>We constructed a mathematical model for the transmission of Schistosoma mekongi in Cambodia. The simulation of the model will be instrumental in planning schistosomiasis control measures. The model includes two definitive hosts, humans and dogs, as animal reservoirs. Dogs are recognized to play an important role in schistosomiasis transmission in Cambodia. For the purpose of dealing with age-specific prevalence and intensity of infection, the human population was classified into eight age categories in the model. To describe the seasonal fluctuation of the intermediate host population of S. mekongi, the "Post-Spate Survival" hypothesis was adopted for the population dynamics of Neotricula aperta present in the Mekong River. We carried out simulations to evaluate the effect of universal treatment (UT) and targeted mass treatment (TT) with praziquantel on the reduction in prevalence of S. mekongi. The simulations indicated that biyearly UT for 8 years or yearly TT for 5 years after three courses of yearly UT could reduce the prevalence to below 5% when a UT or TT coverage of 85% of inhabitants was achieved. The simulation suggested that the suppression of S. mekongi in Cambodia would be possible by UT or TT with a high coverage rate.</p>
- 2008-09-01
著者
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SOCHEAT Duong
National Malaria Centre
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Socheat Duong
National Malaria Center For Parasitology Entomology And Malaria Control
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Sinuon Muth
National Malaria Center For Parasitology Entomology And Malaria Control
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Matsuda Hajime
Department Of Tropical Medicine And Parasitology Dokkyo Medical University School Of Medicine
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ISHIKAWA Hirofumi
Department of Immunology, Pharmacology Research Labs, Astellas Pharma, Inc.
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CHIGUSA Yuichi
Department of Tropical Medicine and Parasitology, Dokkyo Medical University School of Medicine
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Ishikawa Hirofumi
Department Of Human Ecology Graduate School Of Environment Science Okayama University
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HISAKANE Naoto
Department of Human Ecology, Graduate School of Environmental Science, Okayama University
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KIRINOKI Masashi
Center for Tropical Medicine and Parasitology, Dokkyo Medical University School of Medicine
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CHIGUSA Yuichi
Center for Tropical Medicine and Parasitology, Dokkyo Medical University School of Medicine
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MATSUDA Hajime
Institute of International Education and Research, Dokkyo Medical University School of Medicine
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Matsuda Hajime
Institute Of International Education And Research Dokkyo Medical University School Of Medicine
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Hisakane Naoto
Department Of Human Ecology Graduate School Of Environmental Science Okayama University
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Chigusa Yuichi
Center For Tropical Medicine And Parasitology Dokkyo Medical University School Of Medicine
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Kirinoki M.
Dept. Trop. Med. Parasitol
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Kirinoki Masashi
Center For Tropical Medicine And Parasitology Dokkyo Medical University School Of Medicine
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Kirinoki Masashi
Department Of Tropical Medicine And Parasitology Dokkyo University School Of Medicine
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Chigusa Yuichi
Center For Tropical Medicine And Parasitology Dokkyo Medical University
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Kirinoki M.
Inst. Biol. Sci. Univ. Tsukuba
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Kirinoki M.
Inst. Of Biol. Sci. Unv. Of Tsukuba
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Ishikawa Hirofumi
Department Of Environmental And Mathematical Sciences Faculty Of Environmental Science And Technolog
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