Impact of Unnatural Nucleosides on the Control of Microbial Growth

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概要

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• This research investigated the antimicrobial activities of unnatural nucleosides. We tested the MIC and MBC of 17 synthetic nucleoside analogues against 10 microbial strains. These nucleoside analogues were classified into four groups according to their structural characteristics. Inhibition was observed with compounds 1-1, 3-1, and 4-3. In particular, 5-deoxythymidine (3-1) was most effective at 50μg/mL against Bacillus subtilis and Staphylococcus aureus. This analogue has had the hydroxyl group at the 5 position replaced with a hydrogen atom. All compounds had weak effects against various species of mold. The MBC of 5-deoxythymidine was 50μg/mL in 0.5 h against S. aureus. These results showed that 5-deoxythymidine had the most effective antimicrobial activity of the 17 different unnatural nucleosides. The inhibitory effect of 3-1 suggests that it may be useful as an antibacterial agent in medical situations.

• 日本防菌防黴学会の論文
• 2009-06-10

著者

• Hatano Akihiko

  Department Of Materials And Life Science Shizuoka Institute Of Science And Technology

• Souta Ikuo

  Department Of Materials And Life Science Shizuoka Institute Of Science And Technology

• NISHIMURA MAKOTO

  R & D Center, Permachem Asia, Ltd.

• Hatano Akihiko

  Shibaura Inst. Technol. Saitama Jpn

• Hatano Akihiko

  Department Of Chemistry Shibaura Institute Of Technology

• Nishimura Makoto

  Permachem Asia Ltd. Kanagawa Jpn

関連論文

• Aerobic Oxidation of Thiols to Disulfides Catalyzed by Trichlorooxyvanadium
• Impact of Unnatural Nucleosides on the Control of Microbial Growth
• Inhibitory Effects on Microbial Growth Using the Derivatives of Benzyl Phenyl Sulfide
• Importance of 3'-Hydroxyl Group of the Nucleosides for the Reactivity of Thymidine Phosphorylase from Escherichia coli

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