Stereoselective syntheses of (E)-α,β-didehydroamino acid and peptide containing its residue utilizing oxazolidinone derivative
スポンサーリンク
概要
- 論文の詳細を見る
Reaction of methyl N-Boc-N-phenoxycarbonylglycinate with various aldehydes afforded the corresponding cis-4,5-oxazolidinone derivatives, which were effectively converted to (E)-α,β-didehydroamino acids by means of a base. Furthermore, N-deprotection of the oxazolidinone derivatives and subsequent coupling reaction with Boc-amino acid furnished the corresponding dipeptides, which were transformed to dipeptide containing α,β-didehydroamino acid with high E selectivity.
- 日本化学会 = The Chemical Society of Japanの論文
- 2009-03-15
著者
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Kinoshita Hideki
Division Of Material Sciences Graduate School Of Natural Science And Technology Kanazawa University
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KOMETANI Miki
Division of Material Sciences, Graduate School of Natural Science and Technology, Kanazawa Universit
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IHARA Kohki
Division of Material Sciences, Graduate School of Natural Science and Technology, Kanazawa Universit
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KIMURA Rumi
Division of Material Sciences, Graduate School of Natural Science and Technology, Kanazawa Universit
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Ihara Kohki
Division Of Material Sciences Graduate School Of Natural Science And Technology Kanazawa University
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Kometani Miki
Division Of Material Sciences Graduate School Of Natural Science And Technology Kanazawa University
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Kimura Rumi
Division Of Material Sciences Graduate School Of Natural Science And Technology Kanazawa University
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- Stereoselective syntheses of (E)-α,β-didehydroamino acid and peptide containing its residue utilizing oxazolidinone derivative
- Stereoselective Syntheses of (E)-α,β-Didehydroamino Acid and Peptide Containing Its Residue Utilizing Oxazolidinone Derivative