擬似分子内反応による高効率な合成手法の開発
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概要
- 論文の詳細を見る
A highly effective reaction is described, which involves the pseudo intramolecular process. The acyl groups of β-keto esters are activated by α-arylation or α-nitration, and are easily transferred to amines without forming any by-product. This reaction is initiated by forming ammonium enolate. When the amine is liberated under equilibrium, the nucleophilic amine and the electrophilic keto ester are close together, which undergoes the effective substitution like the intramolecular reaction despite the intermolecular reaction; it is called pseudo intramolecular process. This concept is applicable to other substrates having both acidic hydrogen and functionality to furnish polyfunctionalized compounds those are not easily prepared by alternative procedure.
- 社団法人 有機合成化学協会の論文
- 2009-04-01