脱離エレクトロスプレーイオン化質量分析用イオン源の試作と迅速分析への応用

概要

論文の詳細を見る
High-performance liquid chromatography/mass spectrometry (LC/MS) is the most useful tool for qualitative and quantitative chemical analysis in the life sciences. However, sample preparation and LC separation demand an extraordinary amount of time and effort. Desorption electrospray ionization (DESI) and direct analysis in real time (DART) techniques that obtain mass spectra of samples without difficulty have been developed in recent years. We connected a home-built DESI ion source to an existing mass spectrometer and examined its performance. In this paper, we report the application of DESI to thin-layer chromatography (TLC)/DESI-MS in rapid analysis of medicines in serum and concentrated analysis with a solid-phase extraction disk.
日本質量分析学会の論文
2009-04-01