PICK1 is not a susceptibility gene for schizophrenia in a Japanese population: Association study in a large case–control population

概要

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The protein interacting with C-kinase 1 (PICK1) has been implicated in thesusceptibility to schizophrenia. PICK1 interacts with enzymes and receptors that playroles in the pathogenesis of schizophrenia via glutamatergic dysfunction. Recently, twostudies reported associations between schizophrenia and two PICK1 genepolymorphisms, rs3952 in Chinese and Japanese populations and rs2076369 in aJapanese population. We attempted to confirm these associations in a case-control studyof 1765 Japanese patients with schizophrenia and 1851 Japanese control subjects.Neither polymorphism was associated with schizophrenia (rs3952, p = 0.755;rs2076369, p = 0.997). A haplotype block with these polymorphisms spanning the 5’region of the PICK1 gene showed high linkage disequilibrium in the Japanesepopulation (D’ = 0.98, r2 = 0.34); however, neither haplotype was significantlyassociated with schizophrenia. We conclude that the common haplotypes andpolymorphisms of the PICK1 gene identified thus far are unlikely to contribute togenetic susceptibility to schizophrenia in the Japanese population.
Elsevierの論文
2007-06-01