Molecular Design Targeting Repeat Sequences in Human Genome
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概要
- 論文の詳細を見る
The small ligands that bind to the mismatched base pairs were found to stabilize the hairpin secondary structures of the repeat sequences found in the human genome. The trinucleotide repeats are the causatives of many neurological disorders.A whereas the telomere repeats are the sequence located in the 3 end of the human chromosome and stabilize the genome. The ligands described here induced the hairpin secondary structure upon binding to these repeat sequences.
- 社団法人 有機合成化学協会の論文
- 2008-11-01
著者
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Nakatani Kazuhiko
Department Of Regulatory Bioorganic Chemistry The Institute Of Scientific And Industrial Research (i
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Nakatani Kazuhiko
Department Of Regulatory Bioorganic Chemistry The Institute Of Scientific And Industrial Research (s
関連論文
- Noncovalent Assembly of TEMPO Radicals Pair-wise Embedded on a DNA Duplex
- Interstrand Crosslink for Discrimination of Methylated Cytosines
- Molecular Design Targeting Repeat Sequences in Human Genome
- Design of DNA-Cleaving Agents
- Assembly of a Small DNA Rectangular Parallelepiped Block into Higher Order Nanostructures