Diurnal Rhythmicity in the Transcription of Jejunal Drug Transporters

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概要

• 論文の詳細を見る

• Intestinal drug efflux proteins play a major role in the pharmacokinetics of many drugs. We assessed diurnal rhythmicity in the expression of ten major drug transporters. We acquired male Sprague-Dawley rats and harvested jejunal mucosa at 3-h intervals across a 24-h period. qPCR was performed for ten transporters: Mdr1, Mdr3, Mrp1 – 3, Mct1, Brcp, Pept1, Octn2, and Oatp-b. Rhythmicity was assessed with the cosinor procedure. Diurnal rhythmicity was observed for Mdr1, Mct1, Mrp2, Pept1, and Bcrp (1.6 – 5.4-fold-changes). Acrophases occurred during fasting hours. We conclude that many drug transporters display profound diurnal rhythms in transcription, which may underlie diurnal rhythms in drug pharmacokinetics.

• 社団法人 日本薬理学会の論文
• 2008-09-20

著者

• Stearns Adam

  Department Of Surgery Brigham & Women's Hospital / Harvard Medical School

• Balakrishnan Anita

  Department Of Surgery Brigham & Women's Hospital / Harvard Medical School

• BALAKRISHNAN Anita

  Harvard Medical School

• RHOADS David

  Department of Surgery, Brigham & Women's Hospital

• ASHLEY Stanley

  Harvard Medical School

• TAVAKKOLIZADEH Ali

  Pediatric Endocrine Unit, MassGeneral Hospital for Children

• Rhoads David

  Pediatric Endocrine Unit Massgeneral Hospital For Children / Harvard Medical School

• Ashley Stanley

  Department Of Surgery Brigham & Women's Hospital / Harvard Medical School

• Ashley Stanley

  Department Of Gastrointestinal And General Surgery Brigham And Women's Hospital Harvard Medical

• Tavakkolizadeh Ali

  Department Of Surgery Brigham & Women's Hospital / Harvard Medical School

関連論文

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