Enhancement of Trk Signaling Pathways by the Cholestane Amide Conjugate MCC-257
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概要
- 論文の詳細を見る
The cholestane amide conjugate MCC-257 has been shown to augment the effects of nerve growth factor (NGF) on cell survival and on tyrosine phosphorylation of the TrkA receptor in PC12 cells. Recent findings suggest that signaling pathways downstream of Trk are regulated independently. We describe here our finding that the NGF-induced phosphorylation of both ERK and Akt are accelerated by MCC-257. Analysis of the common features of the augmented pathways suggests that TrkA is most likely to be the primary target of MCC-257 and that both ERK and Akt may be involved in the cellular effects of this compound.
- 社団法人 日本薬理学会の論文
- 2008-09-20
著者
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Konishi Yoshiyuki
Department of Molecular Anatomy, Hamamatsu University School of Medicine
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Setou Mitsutoshi
Hamamatsu University School of Medicine
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Setou Mitsutoshi
Department Of Molecular Anatomy Hamamatsu University School Of Medicine
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Konishi Yoshiyuki
Department Of Molecular Anatomy Hamamatsu University School Of Medicine
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YAMADA Maki
Laboratory of Molecular Gerontology, Mitsubishi Kagaku Institute of Life Sciences (MITILS)
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KONISHI Yoshiyuki
Laboratory of Molecular Gerontology, Mitsubishi Kagaku Institute of Life Sciences (MITILS)
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KAKINOKI Bunpei
Pharmacology Department IV, Pharmacology Laboratory, Research Division, Mitsubishi Tanabe Pharma Cor
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IKEGAMI Koji
Laboratory of Molecular Gerontology, Mitsubishi Kagaku Institute of Life Sciences (MITILS)
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SETOU Mitsutoshi
Laboratory of Molecular Gerontology, Mitsubishi Kagaku Institute of Life Sciences (MITILS)
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Kimura Yoshishige
Department Of Molecular Anatomy Hamamatsu University School Of Medicine
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Ikegami Koji
Department Of Molecular Anatomy Hamamatsu University School Of Medicine
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Yamada Maki
Laboratory Of Molecular Gerontology Mitsubishi Kagaku Institute Of Life Sciences (mitils)
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Kakinoki Bunpei
Pharmacology Department Iv Pharmacology Laboratory Research Division Mitsubishi Tanabe Pharma Corpor
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Setou Mitsutoshi
Laboratory Of Molecular Gerontology Mitsubishi Kagaku Institute Of Life Sciences (mitils)
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YAMADA Maki
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo
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