Cerebrospinal Fluid S-100B Concentrations in Normal and Diseased Cattle

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概要

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• We measured the concentrations of S-100B, a marker protein used in humans to detect brain damage, in the cerebrospinal fluid (CSF) of clinically normal cattle (n=15, mean age ± SD: 31.8 ± 37.5 months) and of cattle with various inflammatory disorders (n=43, 70.6 ± 31.9 months). The mean ± SD CSF S-100B level was 2.9 ± 1.6 ng/ml in the normal group and 7.0 ± 7.4 ng/ml in the diseased group. Thirteen diseased cattle that had developed no obvious neurological signs showed abnormally high S-100B concentrations (> 8.0 ng/ml), whereas the two cattle with neurological disorders did not. No particular disease could be related to the S-100B rise. Therefore, it remains inconclusive whether measurement of CSF S-100B concentration is useful in veterinary neurological diagnosis.

• 社団法人　日本獣医学会の論文
• 2005-06-25

著者

• Shimada Nobuaki

  Department Of Safety Research National Institute Of Animal Health

• Murata Hideo

  Department Of Safety Research National Institute Of Animal Health

• Murata Hideo

  Department Of Chemistry Technological University Of Nagaoka

• Inoue Takamasa

  Chubu Livestock Hygiene Center

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