Molecular Interactions of Commensal Enteric Bacteria with the Intestinal Epithelium and the Mucosal Immune System
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概要
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In the last few years, advances in immunology and the analysis of the gut microbial ecology have shown that the contribution of the intestinal microbiota to the overall health status of the host has been so far underestimated. In this context, intestinal epithelial cells play a crucial role in the maintenance of intestinal homoeostasis. Indeed, at the interface between the luminal content and host tissues, the intestinal epithelium must integrate pro- and anti-inflammatory signals to regulate innate and adaptative immune responses, i.e., to control inflammation. Specifically, the regulation of endoplasmic reticulum stress responses in the epithelium is a novel aspect for the pathogenesis of chronic intestinal inflammation. Thus, under the influence of environmental factors, disturbance of the dialog between enteric bacteria and epithelial cells contributes to the development of chronic inflammation in genetically susceptible hosts.
- 日本ビフィズス菌センターの論文
- 2008-04-01