Ligand Recognition by β3 Integrins

スポンサーリンク

概要

• 論文の詳細を見る

• Integrins are alpha/bets heterodimeric adhesion receptors. αIIbβ3 (GPIIb-IIIa) and αvβ3 (the vitronectin receptor) share the same beta subunit, S3, but have distinct alpha subunits. These sister integrins not only recognize many of the same ligands but also have certain unique ligands. Based upon current information in the literature, we propose that four classes of β3 ligands can be distinguished. Since the β3 integrins have multiple functions in vivo and are targets for therapy, this classification system may be useful in the design and characterization of therapeutic agents.

• The Keio Journal of Medicineの論文
• 1997-09-01

著者

• Plow Edward

  Department Of Molecular Cardiology Joseph J Jacobs Center For Thrombosis And Vascular Biology The Cl

• Plow Edward

  Department Of Molecular Cardiology Center For Cardiovascular Genetics Department Of Cardiovascular M

• Suehiro Kazuhisa

  Department Of Molecular Cardiology Joseph J Jacobs Center For Thrombosis And Vascular Biology The Cl

関連論文

• Association between four SNPs on chromosome 9p21 and myocardial infarction is replicated in an Italian population
• Ligand Recognition by β3 Integrins

スポンサーリンク