Peginterferon alpha-2b + ribavirin 併用療法の効果判定における COBAS AmpliPre/COBAS TaqMan HCV test の有用性

概要

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We evaluated the performance characteristics of Amplicor HCV v2.0 (Amplicor HCV) and COBAS AmpliPre/COBAS TaqMan HCV test (TaqMan HCV) for predicting sustained virological response (SVR) at 4, 8, and 12 weeks in patients treated with peginterferon plus ribavirin therapy. In genotype 1, the percentage of patients having SVR with undetectable HCV RNA by TaqMan HCV at 8 and 12 weeks is higher than that by Amplicor HCV (90.0% and 72.2% vs 84.6% and 60.0%). However, in genotype 2, there was no difference between Amplicor HCV and TaqMan HCV. We believe TaqMan HCV is useful for determining the duration of treatment with peginterferon plus ribavirin therapy, especially in genotype 1.
2008-04-25