微小粒子状物質の生体影響 : 自律神経への影響を測定する

概要

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Evidence has been accumulated to show that the particulate matter in polluted air is associated with increased cardiovascular morbidity and mortality. Our studies demonstrated that the effect of single intrataracheal instillation of PM2.5 in Spontaneous Hypertensive Rat (SHR) decreased the heart rate (HR) and increased the parasympathetic nervous activity. Five hours exposure to PM2.5 tended to enhance the lung resistance, leading to a decreased in HR and an increase in parasympathetic nervous activity. There were no significant changes in the sympathetic parameter. These results suggest that the cardiac function may play a role in pathogenesis relating to harmful effect of PM2.5 on SHR. More comparative study is needed for health effect of PM2.5, ultrafine particles and nanoparticles.
2008-09-20