Developmental localization of potassium chloride co-transporter 2 (KCC2) in the Purkinje cells of embryonic mouse cerebellum
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概要
- 論文の詳細を見る
Developmental shift in GABA actions from depolarization to hyperpolarization occurs as a result of decreasing the intracellular Cl− concentration regulated by K+-Cl− co-transporter 2 (KCC2). To clarify the time-course of the developmental shift on the Purkinje cells, we examined KCC2-localization in the embryonic mouse cerebellum. The KCC2 was first detected within the Purkinje cells in the Purkinje cell layer of the hemisphere at embryonic day 15 (E15) and the vermis at E17, but the ventricular and intermediate zones were negative. These results suggest that GABA might become inhibitory on the Purkinje cells after their settling in the Purkinje cell layer.
- Elsevier Ireland Ltdの論文
- 2007-02-01
著者
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Inoue Yoshiro
Department of Cardiology, Saitama Medical Center
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Inoue Yoshiro
Department Of Molecular Neuroanatomy Hokkaido University School Of Medicine
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TAKAYAMA Chitoshi
Department of Anatomy, Hokkaido University School of Medicine
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Takayama Chitoshi
Department Of Molecular Neuroanatomy Hokkaido University School Of Medicine
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Takayama Chitoshi
Department Of Anatomy Hokkaido University School Of Medicine
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Inoue Yoshiro
Department Of Anatomy Hokkaido University School Of Medicine
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