Molecular Design of Polyamines and Related Compounds for Controlled DNA Folding Transition

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概要

• 論文の詳細を見る

• A library of designed DNA compaction agents based on multicationic polyamines, which can fold a DNA polymer chain into condensates with high density due to negative charge neutralization of DNA, are synthesized, and the structure-activity relationship in DNA compaction is investigated. It becomes obvious that the activity is strongly affected by non-electrostatic interactions with DNA, such as hydrophobic (hydrophilic), intercalation, and chirality effects, as well as by efficiency of charge interactions and geometry matching between charged groups of DNA and compaction agents.

• 社団法人 有機合成化学協会の論文
• 2006-11-01

著者

• ZINCHENKO Anatoly

  Department of Material Chemistry, Graduate School of Environmental Studies, Nagoya University

• MURATA Shizuaki

  Department of Material Chemistry, Graduate School of Environmental Studies, Nagoya University

• MURATA Shizuaki

  Graduate School of Environmental Studies, Nagoya University

• Zinchenko Anatoly

  Graduate School Of Environmental Studies Nagoya University

• Zinchenko Anatoly

  Department Of Material Chemistry Graduate School Of Environmental Studies Nagoya University

• Murata Shizuaki

  Graduate School Of Environmental Studies Nagoya University

• Murata Shizuaki

  Department Of Material Chemistry Graduate School Of Environmental Studies Nagoya University

• CHEN Ning

  Graduate School of Environmental Studies, Nagoya University

• CHEN Ning

  Department of Physics, Graduate School of Science, Kyoto University

• Chen Ning

  Graduate School Of Environmental Studies Nagoya University

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