An Experimental Model of Prolonged Esophagitis With Sphincter Failure in the Rat and the Therapeutic Potential of Gastric Pentadecapeptide BPC 157

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概要

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• We report a simple novel rat model that combines prolonged esophagitis and parallel sphincters failure. The anti-ulcer gastric pentadecapeptide BPC 157, which was found to be stable in gastric juice, and is being evaluated in inflammatory bowel disease trials, is an anti-esophagitis therapy that recovers failed sphincters. Twelve or twenty months after the initial challenge (tubes sutured into sphincters for one week and then spontaneously removed by peristalsis), rats exhibit prolonged esophagitis (confluent hemorrhagic and yellowish lesions, thinner epithelium and superficial corneal layer, with stratification derangement); constantly lowered pressure of both sphincters (assessed by using a water manometer connected to the drainage port of a Foley catheter implanted into the stomach either through esophageal or duodenal incision); and both lower esophageal and pyloric sphincter failure. Throughout the esophagitis experiment, BPC 157 was given at either 10 μg/kg, i.p., once a day (last application 24 h before assessment) or alternatively, it was given continuously in drinking water at 0.16 μg/ml (12 ml/rat). This treatment recovers i) esophagitis (macroscopically and microscopically, at either region or investigated time period) and ii) pressure in both sphincters (cmH2O). In addition, BPC 157 (10 μg/kg) or saline (1 ml/rat, 5 ml/kg) was specifically given directly into the stomach; pressure assessment was performed at 5 min thereafter. The effect of BPC 157 is specific because in normal rats, it increases lower esophageal sphincter-pressure, but decreases pyloric sphincter-pressure. Ranitidine, given as the standard drug using the same protocol (50 mg/kg, i.p., once daily; 0.83 mg/ml in drinking water; or 50 mg/kg directly into the stomach) had no effect.

• 社団法人 日本薬理学会の論文
• 2006-11-20

著者

• Petrovic Igor

  Department Of Pharmacology Medical School University Of Zagreb

• DOBRIC Ivan

  Department of Pharmacology, Medical School, University of Zagreb

• DRVIS Petar

  Department of Pharmacology, Medical School, University of Zagreb

• SHEJBAL Drazen

  Department of Pharmacology, Medical School, University of Zagreb

• BLAGAIC Alenka

  Department of Pharmacology, Medical School, University of Zagreb

• BATELJA Lovorka

  Institute of Pathology, Medical School, University of Zagreb

• KOKIC Neven

  Department of Pharmacology, Medical School, University of Zagreb

• TONKIC Ante

  Department of Pharmacology, Medical School, University of Zagreb

• STARESINIC Mario

  Department of Pharmacology, Medical School, University of Zagreb

• RADIC Bozo

  Department of Pharmacology, Medical School, University of Zagreb

• JAKIR Ana

  Department of Pharmacology, Medical School, University of Zagreb

• VUKSIC Tihomir

  Department of Pharmacology, Medical School, University of Zagreb

• ANIC Tomislav

  Department of Pharmacology, Medical School, University of Zagreb

• SIKIRIC Predrag

  Department of Pharmacology, Medical School, University of Zagreb

• BRCIC Luka

  Department of Pharmacology, Medical Faculty, University of Zagreb

• BATELJA Lovorka

  Department of Pharmacology, Medical Faculty, University of Zagreb

• MISE Stjepan

  Department of Pharmacology, Medical Faculty, University of Zagreb

• BAOTIC Tomislav

  Department of Pharmacology, Medical Faculty, University of Zagreb

• SEIWERTH Sven

  Department of Pharmacology, Medical Faculty, University of Zagreb

• Sever Marko

  Department Of Pharmacology University Of Zagreb Medical School

• Jakir Ana

  Department Of Pharmacology University Of Zagreb Medical School

• Radic Bozo

  Department Of Pharmacology University Of Zagreb Medical School

• Brcic Luka

  Institute Of Pathology University Of Zagreb Medical School

• Tonkic Ante

  Department Of Pharmacology Medical School University Of Zagreb

• Drvis Petar

  Department Of Pharmacology Medical School University Of Zagreb

• Kokic Neven

  Departments Of Pharmacology And Pathology Medical Faculty University Of Zagreb

• Dobric Ivan

  Department Of Pharmacology Medical School University Of Zagreb

• Mise Stjepan

  Department Of Pharmacology University Of Zagreb Medical School

• Anic Tomislav

  Department Of Pharmacology University Of Zagreb Medical School

• Seiwerth Sven

  Institute Of Pathology University Of Zagreb Medical School

• Baotic Tomislav

  Department Of Pharmacology University Of Zagreb Medical School

• Shejbal Drazen

  Department Of Pharmacology Medical School University Of Zagreb

• Blagaic Alenka

  Department Of Pharmacology Medical School University Of Zagreb

• Blagaic Alenka

  Departments Of Pharmacology And Pathology Medical Faculty University Of Zagreb

• Vuksic Tihomir

  Department Of Pharmacology Medical School University Of Zagreb

• Batelja Lovorka

  Institute Of Pathology Medical School University Of Zagreb

• Sikiric Predrag

  Department Of Pharmacology University Of Zagreb Medical School

• Sever Marko

  Department Of Pharmacology Medical School University Of Zagreb

• Mise Stjepan

  Department Of Pharmacology Medical Faculty University Of Zagreb

関連論文

• Prolonged Esophagitis After Primary Dysfunction of the Pyloric Sphincter in the Rat and Therapeutic Potential of the Gastric Pentadecapeptide BPC 157
• An Experimental Model of Prolonged Esophagitis With Sphincter Failure in the Rat and the Therapeutic Potential of Gastric Pentadecapeptide BPC 157
• Pentadecapeptide BPC 157, in Clinical Trials as a Therapy for Inflammatory Bowel Disease (PL14736), Is Effective in the Healing of Colocutaneous Fistulas in Rats : Role of the Nitric Oxide-System
• Gastric Pentadecapeptide BPC 157 as an Effective Therapy for Muscle Crush Injury in the Rat
• Stable Gastric Pentadecapeptide BPC 157 in Trials for Inflammatory Bowel Disease (PL-10, PLD-116, PL14736, Pliva, Croatia) Heals Ileoileal Anastomosis in the Rat
• Doxorubicine-Congestive Heart Failure-Increased Big Endothelin-1 Plasma Concentration : Reversal by Amlodipine, Losartan, and Gastric Pentadecapeptide BPC157 in Rat and Mouse

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