Scenario of the twins with suspected congenital rubella syndrome (CRS) in Yangon, Myanmar

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概要

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• Rubella is a common cause of childhood rash and fever. Congenital rubella syndrome (CRS) can lead to deafness, heart disease, cataracts, and a variety of other permanent manifestations. In order to identify the disease burden of rubella infection, CRS surveillance among infants in Yangon was conducted for two consecutive years from December 2000 to December 2002, as a WHO-funded study. Among the 13 participating hospitals, the Special Care Baby Unit of the Central Women‘s Hospital in Yangon reported 17 infants with suspected CRS. Interestingly, three sets of twins with suspected CRS were reported. One ml of blood was collected from each infant after obtaining informed consent, then tested for the presence of rubella antibody (Immunoglobulin M and G) by the ELISA method, and for the presence of rubella viral RNA by the RT-PCR method. Furthermore, nucleotide sequencing and genotype identification of samples from two cases with positive rubella RNA were performed. All 3 sets of twins were IgM negative. However, rubella RNA was detected by RT-PCR in twin 1A who showed no obvious clinical signs, and in twin 2B who had patent ductus arteriosus, splenomegaly and hepatomegaly. Nucleotide sequences of PCR positive cases revealed genotype Ia sequences. Twin 2B was identified as having deafness of the left ear on audiometry assessment conducted at 5 years and 4 months of age. Both twins of twin set-2 were IgG positive at age 12 days, but turned out to be negative by the age of 9 months. Both twins of twin set-3 presented with splenomegaly and died before 2 months of age, probably due to other infections. Our findings revealed the different scenario of twins with suspected CRS. It is expected to serve as a valuable addition to the medical literature as there were very few reports on twins with CRS.

• 2007-09-01

著者

• Myint San-san

  Special Care Baby Unit Central Women's Hospital

• Thant Kyaw-zin

  Department Of Virology Institute Of Tropical Medicine Nagasaki University

• Thant Kyaw-zin

  Department Of Medical Research (upper Myanmar)

• Thein Aye-aye

  Special Care Baby Unit Central Women's Hospital

• Myint Thein-thein

  Department Of Child Health University Of Medicine (1)

• KATOW Shigetaka

  Department of Virology III, National Institute of Infectious Diseases

• Katow Shigetaka

  Department Of Virology Iii National Institute Of Infectious Diseases

• Myint Thein-thein

  Department Of Child Health Institute Of Medicine(i)

関連論文

• Scenario of the twins with suspected congenital rubella syndrome (CRS) in Yangon, Myanmar
• Investigation of Japanese Encephalitis Virus Infection in Bogalay Township, Myanmar in 1999
• Investigation of small-intestinal transit time in normal and malnourished children
• Optimization of the Dengue-2 Antigen ELISA Titer for the Positive Case Detection of Dengue Virus Infection by IgM ELISA
• Molecular epidemiology of rubella virus in Asia : Utility for reduction in the burden of diseases due to congenital rubella syndrome
• Antigen Production of Dengue Type 4 Virus strains in Aedes albopictus clone C6/36 and Vero Cell Cultures

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